Search results for " scalability"
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Techniques for Improving Process Development for Exosome-Derived Therapeutics
We have done this for the first project in our pipeline, scaled it up, and have seen good scalability of performance.
It is important to develop the initial process with a future platform in m…
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Single-use Bioreactors Have Reached the Big Time
In fact, an attractive attribute of single-use bioreactors is their full scalability, according to Adams. Today there are systems available for high throughput R&D through to commercial production. Sa…
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A deep dive into optimizing AAV capture and polishing to maximize both yield and purity
As demand for AAV vectors grows, so does the need for scalable and cost-efficient purification processes. It’s critical to maximize both overall yield and removal of impurities, including empt…
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mRNA: The Messenger - mRNA Product Purification
Join us for part 4 of mRNA : the messenger, where we discuss key considerations for the purification of the mRNA product, including the various methods available and how to consider scalability and su…
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Recombinant Adeno-Associated Virus Type 5 Production Process
A scalable recombinant adeno-associated virus (rAAV) type 5 production process was developed using transfected HEK293 suspension cells.
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Cell culture process development for AAV vector production in suspension cells
Adaptation of HEK293 suspension cell line for transient transfection and scalable adeno-associated virus (AAV) production.
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Technology Innovations Improve Process Chromatography Performance
“Two goals of the biopharmaceutical industry are scalability and flexibility,” notes David Beattie, head of Bioprocessing R&D, MilliporeSigma. “A downstream facility should give reliable product quali…
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Flexible Facilities for Viral Vector Manufacturing
Single-use and modular systems will meet demand for rapid implementation at different scales.
By Jennifer Markarian
Industry experts have noted that there are limitations in the…
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Mapping a Route for Cell and Gene Therapy Process Development
While cell and gene therapies differ in many ways, some of the best practices for process development and validation are similar.
By Cynthia A. Challener
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Single-Use for Downstream Chromatography: Benefit or Hindrance?
Hindrance or help?
Many disposable chromatography columns meet cGMP and industry standards, and also offer reproducibility, scalability, speed, ease-of-use, and operational safety.
However, chr…