Search results for " purity"
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Discovering the unknown: How does in silico process development change PD scientists’ work?
This resulted in improvements in purity and yield of a mixed mode chromatography purification step, and doubled productivity. Mechanistic modeling can also support early-phase development. The technol…
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As the therapeutic pipeline diversifies, chromatography toolboxes are expanding.
Depending on the structure of the target antibody and the impurity profile, other affinities, like protein L or variants of protein A, may improve purity and increase removal of impurities.
Cytiva…
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Chromatography for the Diversified Antibody Pipeline
I believe we have an intense program on trying to address all the different aspects to receive good purity of the future drugs. The full process of an interaction depends on the amount of water consum…
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Report from the 12th Plasma Product Biotechnology Forum
One of the conclusions from the study was that with just six calibration runs, the model could predict the evolution of yield and purity for different starting materials. The general trend was conside…
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A better way to purify small drug volumes
But purifying viral vectors with methods optimized for other products can affect yield, purity, and cross-contamination.
How does the ÄKTA ready™ 450 system tackle those problems?
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Cell-free Expression Systems Pose Cell Culture Alternative
New technologies for rapid, in-line assessments of product concentration, potency, and purity are also needed. Meanwhile, new analytical, quality assurance, and regulatory approaches are needed to imp…
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Setting Up Bioprocessing Systems for Digital Transformation
Harvey Branton, technology lead, Biologics, CPI, uses the following as a “for example” scenario: step elutions tend to be used from chromatography columns so that the product purity is based on a fixe…
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The Importance of Process Intensification and PAT for Achieving Real-Time Release
Electrophoretic technologies, which are the gold standard for purity, charge heterogeneity, and other analyses, present more challenges due to the need for sample preparation. Mass spectrometry is of …
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Virus-like Particles as Therapeutic Moieties of the Future
Sodium dodecyl sulphate–polyacrylamide gel electrophoresis (SDS–PAGE) can be used to analyze the molecular weight and protein purity of VLPs. The identity of individual capsid proteins can be confirme…
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Technology Innovations Improve Process Chromatography Performance
Specific affinity resins are also being developed that enable an effective and straightforward capture step that results in high purity. We can see this trend in new biological targets (e.g., adeno-as…