Search results for " perfusion"
Article
Digitalization: The Route to Biopharma 4.0
Semi-Continuous Scale-Down Models for Clone and Operating Parameter Screening in Perfusion Bioreactors. Biotechnol Prog. 2019, 35 (3), e2790. DOI: 10.1002/btpr.2790.
5. Wolf, M.; Bielser, J. M.;…
Article
Commercial Production of Gene Therapies Using Suspension or Adherent Cell Lines
In FBRs, nutrients and gasses are provided to the cells through circulation or perfusion of the medium through the fixed bed while the cells are immobilized. The cells are only in contact with the imp…
Article
Start-to-Finish Connected Manufacturing
That’s why we are demonstrating our mAb process that tested the performance of a new Xcellerex automatic perfusion system (APS) bioreactor, compared resin and fiber-based chromatography, and utilized …
Article
The New World of Biopharmaceutical Manufacturing
Levison (Pall): The real bottleneck is in the upstream (cell culture), which is why there is so much interest in perfusion technologies for continuous cell culture. Bioprocesses cannot be fully contin…
Poster
One-step seed culture expansion from one vial of high-density cell bank to 2000 L production bioreactor
This application note describes how perfusion cell culturing can be used to reduce processing time, simplify operations, and maximize equipment utilization in seed culture expansion processes.
Article
Paring Down Impurities in Downstream Processing
Bioreactors to house these systems might be stirred-tank, air-lift, fixed-bed, hollow-fiber perfusion, or suspension, perhaps even hybrid combinations thereof. All of these lead to a gamut of membrane…
Article
Report from the 6th International HTPD Conference
…xing in individual cells on the plate has evolved, along with case studies on microwell-based pseudo perfusion bioreactors. The presentation concluded with an outlook of future research areas which i…
Article
Explore the Process Intensifier App
Explore alternatives to intensify your processes >>
How do you know if an intensification approach will give you advantages over your current biomanufacturing process, and how do you choose the …
Webcast
Strategies and emerging technologies for mAb capture
Strategies will depend on the mode of upstream operations (fed batch or perfusion) and the desired process improvement of the capture step, e.g., productivity, cost, or process time, as well as the ty…
Article
Strategies and Emerging Technologies for mAb Capture
Strategies will depend on the mode of upstream operations (fed batch or perfusion) and the desired process improvement of the capture step, (e.g., productivity, cost, or process time) as well as the t…