Search results for "hcp"
Article
Comparing Protein A Resins for Monoclonal Antibody Purification
Table two
The results show that the step yield was consistently over 95%, and high log-reduction factors of host-cell proteins (HCP) and DNA were achieved (see Figure 1). In this study, car…
Article
Get Started: Purification of mAb Variants - eLearning
These molecules show wider variation in binding affinities and are often more challenging to separate from impurities, such as host cell proteins (HCP), host DNA, aggregates, and isoforms.
In this …
Article
How to program, run and evaluate a design of experiments (DoE)
An application example showcases how to optimize an antibody purification for low dimer-and-aggregate and host cell proteins (HCPs) content while achieving best possible yields.
Take the course now…
Article
Getting a Handle on Biopharma’s Most Critical Quality Attributes and Quality Control
They then prioritized attributes based on their importance, and found the following to be key:
• Glucose
• Aggregates
• Host cell protein (HCP)
• Cell viability
• Viable cell densi…
Article
Webinar On Demand: Expanding SPR Uses in Antibody Effector Function Determination
CQAs typically include data on how the candidate interacts with target proteins, as well as process-related CQAs such as protein size, homogeneity, presence of host cell proteins (HCP) etc.
In th…
Article
Preclinical Evaluation of Product Related Impurities and Variants
Further, enzyme linked immunosorbent assay (ELISA) and PicoGreen assays were performed to measure levels of host cell proteins (HCPs) and host cell DNA (HCD), respectively.
Biological characte…
Article
Biopharma Advances Demand Specialized Expertise
The complexity of biotherapeutics often results in considerable technical difficulties as, for example, in the area of impurities; recognition of host- cell proteins (HCPs) and identification of struc…