Search results for "cleaning"
Article
Efficient Cleaning-In-Place Methods for Protein-Based Antibody Affinity Chromatography Resins
Various cleaning strategies and the impact of different cleaning agents and concentrations on the resin lifetime are presented. As the use of sodium hydroxide (NaOH) is considered standard in the biop…
Article
Technical and Process Economical Aspects of Using Capto™ Q and ReadyToProcess™Adsorber Q in mAb Polishing
… membranes can help reduce capital investment, consumption of buffers and other process liquids for cleaning and storage, as well as process time, for example, by minimizing the need for cleaning and…
Article
Single-use technologies in downstream process intensification
When using conventional chromatography solutions, cleaning and cleaning validation consumes a considerable amount of time and facility resources. Cleaning-in-place protocols are performed before, duri…
Article
Technology Innovations Improve Process Chromatography Performance
Reducing the costs for cleaning and cleaning validation are also challenges that many big companies and contract manufacturing organizations (CMO)/contract development and manufacturing organizations …
Article
Reducing Cross-Contamination Risks in Process Chromatography
“With typical bioprocessing tools, a lot of effort and care goes into cleaning and cleaning validation of contact surfaces since any contamination in the purification process can be detrimental to the…
Article
Re-use of Protein A Resin: Fouling and Economics
…selective buffer to remove non-binding impurities; elution at low pH and conductivity; and finally, cleaning and sanitization of the column for next use. The widespread applicability and similarity o…
Article
Ensuring the Biological Integrity of Raw Materials
Protocols for control of contamination in raw materials rely on cleaning and decontamination procedures combined with rigorous testing. These procedures are effective for most agents, but some organis…
Article
Using Single-Use Technologies in Downstream Processing
Mehta states that the use of SUS in downstream processing may “reduce risk of cross contamination and carryover due to inadequate cleaning steps.”
BioPharm International spoke with Nilesh Mehta ab…
Article
Improving mAb Manufacturing Productivity by Optimizing Buffer and Media Prep Process Flow
Single-use raw material delivery systems, in powder or liquid form, can help reduce the risk of contamination and minimize the need for frequent cleaning steps. Raw material quality control (QC) testi…
Article
Single-Use for Downstream Chromatography: Benefit or Hindrance?
Single-use technology is gaining ground in downstream bioprocessing, but challenges stall further adoption.
By Feliza Mirasol
ARTMOIS/STOCK.ADOBE.COM
Biopharmaceutical manufactu…