Search results for " Virus production"
Poster
Development of a chemically defined medium for virus vaccine production in a duck suspension cell line
A project was initiated to improve the production process for viral vaccines through the use of the EB66® cell line derived from duck embryonic stem cells and proprietary to Valneva. The primary goa…
Poster
Validation of Cytodex™ Gamma microcarrier-based virus production in single-use bioreactor systems
A majority of cell lines commonly used for viral vaccine production are anchorage-dependent and require expansion on solid surfaces. Here, we describe different approaches for the cultivation of Ver…
Article
Recombinant Adeno-Associated Virus Type 5 Production Process
A scalable recombinant adeno-associated virus (rAAV) type 5 production process was developed using transfected HEK293 suspension cells.
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Article
rAAV Production Using HEK293 Cell Line and Transfection Medium
Improving the performance of a scalable AAV process in Xcellerex™ XDR-10 and XDR-200 bioreactor using HyClone™ peak expression medium.
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Article
Flavivirus Vaccine: Accelerate Development and Production with Modern Tools and Solutions
The complex nature of flaviviruses makes process development technically challenging. In addition, vaccine production can be both costly and difficult to scale to meet market demands. This article giv…
Article
Scalable ADCF Virus Production Using HyClone™ VaccineXpress Medium
In this study, HyClone VaccineXpress cell culture medium was used for the propagation of influenza virus and rotavirus in an animal-derived component-free (ADCF) process. Small-scale microcarrier cu…
Article
Case Study: Process for Production of Oncolytic Adenovirus
The promising results from clinical studies on the use of viral vectors to address important medical needs have spurred interest in developing scalable and cost-efficient manufacturing processes. Here…
Article
Production of Recombinant Adeno-associated Virus Vectors Using Microcarrier Culture of HEK293T Cells
As of March 2020, more than 4310 gene therapy clinical trials have been performed worldwide, with only 518 of them in Phase III and Phase IV. As the gene therapy projects enter clinical Phase III or g…
Article
Case Study: Oncolytic Adenovirus Production
Oncolytic viruses constitute a promising therapeutic approach for treatment of cancer. These viruses selectively replicate in tumor cells and effectively kill these cells without harming normal cell…
Poster
A Scalable Adenovirus Production Process, from Cell Culture to Purified Bulk
Adenovirus (AdV) vectors are commonly used in cancer gene therapy trials and evaluated for use in vaccines for various diseases. In this study, we have combined technical evaluation of process steps a…