Search results for " recombinant protein"
Article
A Look at the Affinity Chromatography Landscape
“Engineered recombinant Protein A resins with smaller bead sizes are often suitable for bispecific antibodies with Fc regions, while for bispecific molecules without Fc regions, other affinity resins …
Article
Improving Process-Scale Chromatography
Advances in technology are increasing the productivity and efficiency of commercial-scale chromatography bioprocesses.
By Cynthia Challener, PhD
Chromatography is a crucial step in the purif…
Article
Antibody Production in Microbial Hosts
With more than 200 recombinant proteins on the market today, the biopharmaceutical industry is expected to reach approximately $180 billion by 2016 (1). Therapeutic mAbs and their derivatives—such as …
Article
Process Chromatography: Continuous Optimization
… purification process making it simpler and more economical for a variety of molecules from mAbs, to recombinant proteins, to viruses.
Hydrophobic interaction resins separate molecules based on d…
Article
Innovative Chromatography Resins Can Improve Purity and Quality
Development of an individual, multi-step chromatography downstream processing (DSP) for every recombinant protein anew increases overall development costs and timelines, and hence prolongs time-to-mar…
Article
Concentrating Feed—an Applicable Approach to Improve Antibody Production
These straightforward approaches can be applied to large-scale production of recombinant proteins.
Materials and methods
Cell lines. Three recombinant Chinese hamster ovary (CHO) cell li…
Article
Novel Vaccine Technologies Meet the Need for Pandemic and Therapeutic Solutions
Examples include cell-culture, synthetic DNA, chimeric antigen, and recombinant protein nanoparticle vaccine technologies.
Egg-vaccine technology limitations
Traditional vaccine manufactu…
Article
Single-Domain Antibodies for Brain Targeting
Thus, nearly all large molecules (molecular weight >1 kDa) such as recombinant proteins or gene-based medicines are unable to cross the BBB.
Conventional antibodies are unable to cross the BBB. An…
Article
Cell-free Expression Systems Pose Cell Culture Alternative
During a short period of time, the system can make protein biologics with high efficiency with minimal by-products, and you don’t have to worry about proteolytic of recombinant protein caused by prote…
Article
Advances in Engineering of Protein-Based APIs
Advances in Engineering of Protein-Based APIs
New platform technologies, advanced modeling tools, and addressing patient needs are important developments.
By Cynthia A. Challener
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