Search results for " CHO"
Article
Commercial Production of Gene Therapies Using Suspension or Adherent Cell Lines
Adherent cell lines are the most common choice at early stages of development as they are readily sourced, easy to cultivate at the laboratory scale, and require less expert bioengineering know-how.
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Article
Reimagining Affordable Biosimilars
Advances in preclinical development play a crucial role in reducing cost for developing biosimilars.
By Anurag S. Rathore, Narendra Chirmule, and Himanshu Malani
Drug development is …
Article
Upstream PD Time-Saver: Optimize Early
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Optimization is key to achieving a high-producing CHO cell culture. Identify the right combination of culture medium, feed supplements, and feeding strategy …
Article
Best Practices for Selecting a Top-Quality Cell Line
First is the product itself, which can affect the choice parental cell line (e.g., Chinese hamster ovary [CHO] or other type). “The advent of more complex molecules rather than monospecific antibodies…
Article
Scale-Up Model of a mAb Process from Microbioreactor to XDR-1000
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In process development, it is desirable to test process parameters in small scale and later scale up the process into larger production scale. A theoretical scale-up study was per…
Article
Biopharmaceutical Process Development: 2018 Lessons and 2019 Predictions
…Cycles
• Optimization of Fed‑Batch Culture Conditions for a mAb‑Producing CHO Cell Line
• How to Determine Dynamic Binding Capacity (DBC) of Chromatography Resins
Article
Fifteen Years of Progress: Biopharmaceutical Industry Survey Results
Fifteen Years of Progress: Biopharmaceutical Industry Survey Results
This article highlights 15 years of changes in biopharmaceutical manufacturing.
By Ronald A. Rader, Eric La…
Article
Exotoxin Clearance from mAb Samples in a Two-Step Chromatography Process
A heat-stable exotoxin can remain as a contaminant of a drug substance throughout the whole manufacturing process, with the risk of adversely affecting patients’ health. One such toxin is cereulide …
Poster
Strategies for optimized cell culture media: Effectively using design space to influence product quality
Here we highlight a statistical design strategy to optimize cell culture media to influence the charge variant profile of a mAb produced in CHO DG44 cells.
Media optimization requires incorp…
Article
Ensuring the Biological Integrity of Raw Materials
By Catherine Shaffer
Contamination with microbes, mycoplasma, viruses, and other adventitious agents can be a significant problem in biopharmaceutical manufacturing. Although contamination can o…