Search results for " fluid"
Article
Digitalized PD: Speeding up downstream process development
Mechanistic models enable the simulation of chromatography processes based on fundamental natural laws, such as fluid dynamics and thermodynamics. In silico simulations of chromatography proce…
Webcast
Xcellerex™ X-platform bioreactor live virtual demo
In this virtual workshop Ken Clapp will explain how we developed the Xcellerex™ X-platform bioreactors using a verified computational fluid dynamics model. Thomas Falkman and Sanna Tronnersjö will joi…
Article
Xcellerex™ X-platform bioreactor live virtual demo
In this virtual event, Ken Clapp will explain how we developed the Xcellerex™ X-platform bioreactors using a verified computational fluid dynamics model. Thomas Falkman and Sanna Tronnersjö will join …
Article
Accelerating VLP purification process development
In contrast, mechanistic models describe the transport of sample components using fluid dynamic and thermodynamic principles. Further, they allow for efficient process optimization in silico.
R…
Article
Mechanistic Modeling: Current Advantages and Future Opportunities in Biopharmaceutical Process Development
Only the fluid dynamic parameters must be adapted to the new scale. The actual interactions of molecules with the ligands on the resin do not change.
In summary, I am convinced that soon, modelin…
Article
Eliminating Residual Impurities Starts with a Strategic Plan
Chandrasekaran notes that most conventional detectors lack the sensitivity to accurately measure residual impurities in process fluids. “Developing a non-denaturing method is critical to avoid inaccur…
Article
Biomanufacturing: Demand for Continuous Bioprocessing Increasing
The classic and still predominant approach to bioprocessing, both upstream and downstream, remains batch processing, with manufacturing batch fluids essentially moving incrementally en-masse from one …
Article
Cell-Culture Advances Test Bioreactor Performance Models
In particular, the inexpensive computing power and excellent computational talent entering the biopharma industry, combined with improvements in computational fluid dynamics (CFD) and metabolic modeli…
Article
Moving PAT from Concept to Reality
On-line sensors are connected to process side streams and perform periodic automatic sampling, returning fluid back to the process streams after analysis is complete. At-line—or off-line—analyses invo…
Article
Emerging Therapies Test Existing Bioanalytical Methods
qPCR is used to quantify a viral genome in serum, tissue, or body fluids for the purpose of pharmacokinetics (PK), biodistribution, or vector shedding evaluations (3,4,6). It is also used to measure t…