Search results for "bispecific"
Article
Fundamentals of hydrophobic interaction chromatography
… molecules:
* recombinant proteins and peptides
* monoclonal antibodies (mAbs), bispecific mAbs and antibody-drug conjugates (ADC)
* mRNA
* plasmid
New to HIC? Browse this …
Article
Antibody purification quiz
How well do you know antibodies and antibody purification?
Test your knowledge and gain insights in the purification of antibody variants – bsAbs, Fab, dAbs.
Article
Pushing the Barriers in Next-Gen Antibody Development
Continued development of new and next-generation antibodies is spurred by the increasing demand for more effective and custom-tailored biologic therapies. In particular, bispecific antibodi…
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Protein L affinity resin is ready to move to manufacturing
Although protein L affinity resins have been available for more than a decade, insufficient binding capacities and alkaline stability challenges have limited their use in productive manufactur…
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Enhancing Resins Addresses Purification Concerns
Existing challenges
Beyond vaccines, biotherapeutic development is seeing the emergence of a variety of other complex modalities, such as bispecific antibodies and protein fragments in addition …
Article
Antibody Production Workflow
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Antibody-based therapies have evolved beyond monoclonal antibodies (mAbs) to include bispecific antibodies, antibody fragments, antibody-drug conjugates (ADCs), and m…
Article
Updating Viral Clearance for New Biologic Modalities
“The industry has a way to go in developing a range of viral clearance products that enable efficient separation of more complex mAbs, such as bispecific or Fc-fusion proteins,” he says.
Another c…
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Advancements in Antibody Purification
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The demand for more efficient and agile downstream purification processes for diversified therapeutic antibody pipelines requires the development of new…
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Meeting the Process Development Challenges of a Diverse Biologic Pipeline
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Understanding the challenges novel and diverse biological molecules can create and how to manage these challenges is key to ensuring they reach patients safely and eff…
Article
Technology Innovations Improve Process Chromatography Performance
Bispecific antibodies, antibody-drug conjugates, engineered glycovariants, fusion proteins—all these molecules need to be purified with a templated approach using resins with a predictable behavior,” …