Search results for "viral vector"
Article
New Therapies Present Scaling Challenges
Currently, viral vectors are a popular method used to deliver gene therapy. Mammalian cells are cultivated to produce the viral vector “package”, and—as in cell culturing for mAbs—cell density can be …
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What’s New in Upstream Technologies
The system features a modular, scalable, fixed-bed bioreactor for enhanced upstream processing of viral products, including viral vaccines, viral vectors, and oncolytic viruses. The low-footprint inte…
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Science Focus Fuels Successful Process Development for Startups
…nvolved cell-line engineering as well as determination of the optimum process for production of the viral vector, according to founder and chief operations officer Suma Krishnan. “We built a GMP faci…
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Developing an Efficient Adenovirus Downstream Purification Process
Adenovirus is also explored as a potential viral vector for gene therapy and as an oncolytic virus. This application note describes the development of downstream chromatography steps for purification …
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Achieving Efficient Adenovirus Upstream Production
Adenovirus has also been explored as a viral vector for gene therapy and as an oncolytic virus. This application note describes the production of adenovirus in HEK293 suspension cells in a bioreactor …
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Report from the 6th International HTPD Conference
The biggest challenge is still the people and Quantitative Structure-Activity Relationship (QSAR) plus mechanistic modeling were two key take-home messages from the 6th International conference devote…
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Webcast: Repeatable, automated SPR titer assay for adeno- and adeno-associated viruses in crude samples
Viral vectors are commonly used in clinical trials to evaluate gene therapies. Due to instability, these vectors are difficult to produce and analyze. Current assays lack the sensitivity requi…
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Scalable AAV Production Process for Gene Therapy
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Viral vectors are often used for gene transfer of specific tissue- or cell-type modifications. Several viruses have been investigated for use in cell and gene therapy; adeno-associ…
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2019’s Top Bioprocessing Trends and What to Expect in 2020
Following the high interest in cell and gene therapies, there is a big interest in viral vectors, especially for adeno-associated virus, but also adenovirus. In 2019, a novel production process for ad…
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Evaluation of HEK293 Cell Growth and Adenovirus Productivity in HyClone™ CDM4HEK293 Medium
HEK293 cells are susceptible to infection by adenovirus, one of the most frequently used viral vectors in the development of therapeutic vaccines and vaccines against infectious diseases. This applica…