Search results for " upstream processing"
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Downstream Processing for Cell-Based Therapies
Delivering effective DSP technologies and robust processes with the capacity to target specificity and throughput is required to ensure that advances in upstream processing are maximized. Effective sc…
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Automating Processes in Upstream Processing
BioPharm: What should be considered when developing strategies for process control in upstream processing?
Marshall: The bioreactor or fermenter is the upstream equipment that has the most control…
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Top Process Development Trends for 2021 and a Look into 2022
The COVID-19 pandemic continues to shape bioprocess development trends, and many lessons have been learned from industry’s response to and preparedness for dealing with a public health crisis. Howev…
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Using Digital Twins to Model Process Chromatography
Mechanistic models provide process understanding for developing robust manufacturing processes and for scale up and tech transfer.
By Jennifer Markarian
A digital twin is a model of a proces…
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Overview of a scale-up of a cell-based influenza virus production process using ReadyToProcess equipment
Downstream Processing and Purity Analysis
For downstream laboratory-scale purification, performed using standard, non-disposable equipment, approximately 10 L virus harvest from the upstream proce…
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Process Development: 2020 Reflections and 2021 Possibilities
Bioprocess Development Forum readers also focused on upstream predictability and how companies are exploring process intensification efforts at every stage of upstream processing, which drives improve…
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Generating a Fully Processed Antibody
The authors outline cell-line development and process scale-up for an antibody program in which the antibody requires additional processing by a site-specific enzyme for correct functionality.
B…
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Monitoring and Control of Inline Dilution Processes
Buffer management has received less attention in process intensification despite the high costs and labor-, space-, time-, and material-intensive nature of this common downstream activity.
By…
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Automating the Biomanufacturing Process
As automation in biomanufacturing becomes more important, so does the need to integrate process data.
By Feliza Mirasol
unlimit3d/Stock.Adobe.com
Biomanufacturing proc…
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QbD Improves Cell-Culture Process Control
QbD Improves Cell-Culture Process Control
A quality-by-design approach that implements PAT offers advantages in upstream cell-culture processing.
By Feliza Mirasol
Mar…