Search results for " seed train"
Article
QbD and PAT in Upstream and Downstream Processing
To gain perspective on the implementation of quality by design (QbD) and process analytical technology (PAT) in biopharmaceutical processing, BioPharm International spoke with Clinton Weber, as…
Article
Genetic Vaccine Platforms Demonstrate Their Potential
In a pandemic, genetic vaccines offer several advantages over traditional approaches.
By Cynthia A. Challener
For a vaccine to be effective, the components of the disease o…
Article
Simplifying Cell Culture Expansion
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Controlled perfusion in a closed, single-use bioreactor can cut the complexity from your cell culture expansion process, making it possible to go from seed trai…
Article
Next Generation Bioprocesses: Mapping Roads to the Future
In upstream processing, this can be exemplified by intensified seed train or intensified production bioreactor operations. In downstream processing, it can be intensified capture, in-line virus inacti…
Article
Being Thorough When Transferring Technology
Communication and taking the time to develop the process are key to successful transfer and scale up of biologics.
By Susan Haigney
Editor's note: The following is an extended version of the…
Article
A Risk-Based Genetic Characterization Strategy for Recombinant CHO Cell Lines Used for Clinical and Commercial Applications
In experience with the authors’ CHO cell lines, a typical cell age from a 5000-L production bioreactor is found to be approximately 30 PD including the cell age of a WCB, seed train, and bioreactor ex…
Article
Modular Manufacturing Platforms for Biologics
May 01, 2015
By Randi Hernandez
BioPharm International
Volume 28, Issue 5
It should come as no surprise that the good design principles governing the execution of pharmaceutical manu…