Search results for " in silico"

Article Accelerating CMC - The future of process development is in silico
Simulation for in silico process development is becoming a viable option to reduce the time needed for chemicals, manufacturing, and control (CMC) activities and increase process understanding. Advanc…

Article In silico Approaches towards Automated Biomanufacturing
As part of manufacturing science and technology (MSAT), mechanistic modeling can be used to support several activities in biopharmaceutical production, including process transfer activities, in silico

Article Using Digital Twins to Model Process Chromatography
By Jennifer Markarian A digital twin is a model of a process that allows process development experiments to be run in silico—on a computer—rather than on actual lab or manufacturing equipment. Alt…

Article HTPD 2023 conference is coming up. What will be discussed and what happened last time?
The sessions guided by Cytiva modeling specialists will cover an introduction to the topic, benefits, and basic workflows of in silico process development and a deep dive into case studies and further…

Article Insider Recommendations for Getting Started with Mechanistic Modeling of Chromatography
6:50 - Key benefits of in silico process development driven by mechanistic models. Visit cytiva.com/modeling for more information about mechanistic modeling. Video Transcript …

Article Mechanistic Modeling: Current Advantages and Future Opportunities in Biopharmaceutical Process Development
After calibration, process parameters and the actual process set-up can easily be changed in silico without further experimentation. This opens a wide range of model applications—from early-stage proc…

Article Digitalized PD: Speeding up downstream process development
Mechanistic models enable the simulation of chromatography processes based on fundamental natural laws, such as fluid dynamics and thermodynamics. In silico simulations of chromatography proce…

Article Sign-up to join Chromatography Virtual Summit 2022
High-level agenda: • 15 November: Process development of antibody variants • 16 November: In silico downstream process development — Get started • 17 November: In silico downstream …

Article Using Quality by Design to Develop Robust Chromatographic Methods
In the example, the data from the six experiments are used as the input for in silico optimization experiments. The result is a resolution map and optimized chromatogram within which the optimum condi…

Article Predicting Progress in Protein Aggregation
“We have been successful to date in using such in silico analyses to address the issue of protein aggregation much earlier in the drug development process, which helps avoid potential problems through…

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