Search results for "sanitization"
Article
Selecting a Comprehensive Bioburden Reduction Plan
The identified risks and severity levels inform planning of raw material selection, facility design, process elements and conditions, cleaning and sanitization requirements, establishment of alert/act…
Article
Comparing Protein A Resins for Monoclonal Antibody Purification
…ies, its sensitivity to alkaline conditions prevents the use of rigorous and cost-effective CIP and sanitization protocols based on NaOH.
Compared to conventional Protein A resins, one of the aff…
Article
A Closer Look at Affinity Ligands
As an example, much engineering has recently gone into modifying the Protein A ligand to ensure it can withstand the stringent cleaning and sanitization procedures required for use in a pharmaceutical…
Article
The Importance of Partnering for Bioanalytical Studies
The Importance of Partnering for Bioanalytical Studies
Yakobchuk Olena/Stock.Adobe.com
Bioanalytical studies are an important aspect of biologic drug development that may necessitate…
Article
Single-Use for Downstream Chromatography: Benefit or Hindrance?
Single-use technology is gaining ground in downstream bioprocessing, but challenges stall further adoption.
By Feliza Mirasol
ARTMOIS/STOCK.ADOBE.COM
Biopharmaceutical manufactu…
Article
A Look at the Affinity Chromatography Landscape
Protein A is the most sensitive resin to cleaning-in-place and sanitization processes, and one key issue has been the development of more robust versions that can withstand high pH washes to prevent b…
Article
Chromatography Scale-Up: Don’t Get Tied Down by Bed Height
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When scaling, you can make better use of existing chromatography columns while avoiding overcapacity.
Keeping a constant residence time is a well-est…
Poster
A Next Generation Protein A Chromatography Resin for Improved Productivity and Bioburden Control
…hange and hydrophobic interaction chromatography resins, enabling new possibilities in cleaning and sanitization efficiency to address bioburden risks and process economy. The binding capacity has be…
Article
How to Address Bioburden Challenges: Insights and Tips
Another important area where suppliers can contribute is sanitization and storage procedures for protein A chromatography resins, which are widely used to purify mAbs.
Learn more about insights an…
Article
Bioburden Control in the Biopharmaceutical Industry
Protecting against microbiological contamination over the whole manufacturing process grows increasingly important.
By Mostafa Eissa
The biopharmaceutical industry has witn…