Search results for " bioreactor"
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Bioprocessing Advances in Vaccine Manufacture
This increase included 78% of those surveyed reporting current use of SUS bioreactors and 92% using SUS filter cartridges at some level in bioprocessing (see Figure 1).
SUS have m…
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Mapping a Route for Cell and Gene Therapy Process Development
The biggest challenge, according to Baghbaderani, is the development of large-scale manufacturing processes using 3D computer-controlled suspension bioreactors with appropriate downstream processes. “…
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Scaling Up Novel Therapies
Bioreactor scale-up
In more traditional biopharmaceutical development, bioreactors are typically the most difficult pieces of equipment to scale up, says Fredrik Lundström, product manager for…
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Platform Approach Speeds Process Development
Figure 1: Cell-culture process development concept for Phase I supply including media screening and optimization as well as bioreactor screening optimization modules. For the time scale, one box corre…
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Implications of Cell Culture Conditions on Protein Glycosylation
The choice of host cell and the bioreactor conditions used in bioproduction of proteins significantly affects protein product quality. This is due both to the structural complexity of proteins themsel…
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Continuous Manufacturing: A Changing Processing Paradigm
“Currently, only a minority of bioreactors are specified with perfusion capability; however, there is a clear awareness that new facilities must be flexible and adaptable to perfusion technology,” ass…
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QbD and PAT in Upstream and Downstream Processing
This approach can lead in the determination of CQAs for the cell production bioreactor unit operation. Upstream outputs classified as CQAs have proven to be controversial, because the bioreactor is so…
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Maximum Output Starts with Optimized Upstream Processing
She points to the mAb sector where stainless-steel bioreactors with tens of thousands of liters of capacity were commonly used for cell culture, but today have been replaced with single-use (SU) biore…
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Biomanufacturing: Demand for Continuous Bioprocessing Increasing
Of the nearly 20 technologies identified, the top technologies this year included single-use bioreactors (noted by 45.9% of respondents), followed by cell culture media including optimization, and the…
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Unifying Continuous Biomanufacturing Operations
“For continuous virus production, multi-stage bioreactors are needed, with configurations that can be either cascades of continuous stirred-tank bioreactors (CSTRs) or CSTRs followed by tubular reacto…