Search results for " bioreactor" in Articles / App Notes
Article
Commercial Production of Gene Therapies Using Suspension or Adherent Cell Lines
… offering the advantage of being scalable and readily industrializable using well known stirred tank bioreactors (STRs), as opposed to multi-tray culture systems. To reduce upfront expenses and to ov…
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What’s New in Upstream Technologies
The system features a modular, scalable, fixed-bed bioreactor for enhanced upstream processing of viral products, including viral vaccines, viral vectors, and oncolytic viruses. The low-footprint inte…
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Maximizing the Effectiveness of Upstream Bioprocessing Through the Combination of Lab Informatics and Instrumentation
The increasing popularity of single-use bioreactor systems and continuous processing techniques have brought both new opportunities and challenges to upstream bioprocessing. Together, these trends hav…
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The New World of Biopharmaceutical Manufacturing
Heintz (Solvay): The evolution of single-use containers from several decades ago to today’s gamma irradiation-stable bioreactors has been one of the most significant transformations; it was the impetu…
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Design Considerations for a Commercial Cell and Gene Therapy Facility
Already well-established, mAb production is typically batch-oriented (in this way, making it similar to allogeneic cell therapy production) and characterized by larger single-use bioreactor skids with…
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Concentrating Feed—an Applicable Approach to Improve Antibody Production
Often in fed-batch processes, the feed volume can be more than 1000 L for a 5000-L bioreactor with 30 to 40% (v/v) feed. To alleviate workload in media preparation and simplify the manufacturing proce…
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Bioprocessing Advances in Vaccine Manufacture
This increase included 78% of those surveyed reporting current use of SUS bioreactors and 92% using SUS filter cartridges at some level in bioprocessing (see Figure 1).
SUS have m…
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Mapping a Route for Cell and Gene Therapy Process Development
The biggest challenge, according to Baghbaderani, is the development of large-scale manufacturing processes using 3D computer-controlled suspension bioreactors with appropriate downstream processes. “…
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Scaling Up Novel Therapies
Bioreactor scale-up
In more traditional biopharmaceutical development, bioreactors are typically the most difficult pieces of equipment to scale up, says Fredrik Lundström, product manager for…
Article
Platform Approach Speeds Process Development
Figure 1: Cell-culture process development concept for Phase I supply including media screening and optimization as well as bioreactor screening optimization modules. For the time scale, one box corre…