Search results for " degradation"
Article
Antibody Production in Microbial Hosts
coli has several cytoplasmic endogenous proteases that can cause proteolytic degradation; this represents a critical disadvantage of E. coli as a production vector. However, this problem has been succ…
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Applications of Surface Plasmon Resonance for Detection of Bispecific Antibody Activity
Characterization of binding events is essential for confirmation of CQAs, plays a vital role in forced degradation studies, and can either complement or form the basis for potency assays. Binding assa…
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Cleaning of Dedicated Equipment: Why Validation is Needed
Moreover, the company failed to put in place intra-campaign controls aimed at verifying that during a production campaign the level of potential degradation residues in the equipment was maintained to…
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Biopharma Advances Demand Specialized Expertise
Jun 15, 2015
By BioPharm International Editors
BioPharm International eBooks
Volume 28, Issue 13
Contract service providers share insights on biopharma market developments and the impl…
Article
Optimization of Protein Expression in Escherichia Coli
Many problems are associated with protein expression, including toxicity, misfolding and degradation, aggregation in inclusion bodies, low yields, and difficulties in purification. One of the most com…
Article
Use of Multivariate Data Analysis in Bioprocessing
Similarly, application of surface-enhanced Raman scattering (SERS) spectroscopy for simple and fast analysis of cell-culture media degradation has been demonstrated (16). In this work, chemometric too…
Article
Quality by Design and Extractable and Leachable Testing
Depending upon the contents, packaging may also serve to shield the drug product from oxidation, light degradation, and moisture permeation. The packaging must clearly identify its contents and may in…
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Trends in Single-use Bioreactors
Recent studies have shown that this can be attributed to a degradation product of a commonly used antioxidant.
Establishing full traceability of raw materials, robust process controls, and meaning…
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Viral Clearance Challenges in Bioprocessing
…sting lab, potentially leading to changes in the process intermediates due to aggregation or product degradation, which can result in different performance for individual unit operations compared to …
Article
Using Quality by Design to Develop Robust Chromatographic Methods
Quality-by-design principles can be used to understand chromatographic measurement system variability.
Sep 2, 2014
By: Melissa Hanna-Brown, Kimber Barnett, Brent Harrington, Tim Graul, Jim…