Search results for " detection"
Article
Use of Multivariate Data Analysis in Bioprocessing
Applications involving multivariate data analysis of these complex data sets to extract relevant information could be aimed at process monitoring in a manufacturing setting by detection of process fau…
Article
Ligand-Binding Assays and the Determination of Biosimilarity
Binding assays work very well for the detection of anti-drug antibodies, and for testing which of those antibodies may have drug-activity-neutralizing potential,” says Sadick.
LBAs vs. CBAs
Bi…
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Improving PAT for Biologics
For biologics that are extracellular and present in relatively large concentrations, there is a good potential for direct detection through the use of spectroscopic measurement techniques. This type o…
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Elucidating Biosimilars Characterization
Glycans are traditionally analyzed using either liquid-phase separation techniques such as liquid chromatography or capillary electrophoresis with optical or fluorescence detection or mass spectrometr…
Article
Eliminating Residual Impurities Starts with a Strategic Plan
The chosen separation and detection technologies must also be suitable to the analysis without degradation of the impurities occurring.
Overall, potential process-related and other residual impu…
Article
Best Practices for Selecting a Top-Quality Cell Line
Irina Shi - Stock.Adobe.com
Leveraging automation and a step-by-step approach are keys to success.
By Cynthia A. Challener
Cell lines determine the performanc…
Article
Moving PAT from Concept to Reality
Examples include high-resolution, specific, robust PAT tools with a low limit of detection and in-line, reusable sensors with high frequency measurements that do not require calibration over the cours…
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Real-Time Characterization of Biotherapeutics and Comparability of Biosimilars
SPR is a well-established technique for detection and monitoring of biomolecular interactions in real time. It has been formatted as a parallel line assay and researchers have demonstrated high levels…
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Managing Residual Impurities During Downstream Processing
This chapter includes a validated sample extraction procedure in combination with a quantitative polymerase chain reaction (qPCR) detection method. Users would need to verify that the chapter method i…
Article
Changing the Culture of Cell Culture: Applying Best Practices and Authentication to Ensure Scientific Reproducibility
For this reason, cell line authentication and QC measures such as mycoplasma detection constitute an essential first step to establish and maintain the integrity of cell cultures and to enhance reprod…