Search results for " cation exchange" in Articles / App Notes
Article
New Selection Guide: Ion Exchange Chromatography Columns and Resins
Use these decision trees to find the most appropriate resin for your needs.
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Article
Modeling the Degradation of mAb Therapeutics
In brief, buffers examined included those commonly used for Protein A chromatography, cation exchange chromatography, and anion exchange chromatography.
Samples were kept at three different te…
Article
The Challenge of Disruptive Technologies in Bioprocessing
Next-generation ion exchange chromatography resins like POROS XS (strong cation exchange) and XQ (strong anion exchange) offer high capacity, high resolution, and salt tolerance at faster flow rates f…
Article
SEC in the Modern Downstream Purification Process
Mar 01, 2015
By R. Christopher Manzari, J. Kevin O'Donnell
BioPharm International
Volume 3, Issue 28
Since the introduction of commercial chromatography resins approximately six de…
Article
Addressing the Complex Nature of Downstream Processing with QbD
It is therefore common to reduce aggregate content to below a threshold value using cation exchange, multimodal chromatography, or hydrophobic interaction chromatography. For this kind of step, it is …
Article
Getting a Handle on Biopharma’s Most Critical Quality Attributes and Quality Control
While the multiple attributes method gains ground and traditional lab methods improve, broad efforts are underway to determine biopharmaceuticals’ most significant critical quality attributes and en…
Article
On-Demand Webinar: A Route to Deeper Process Understanding—Studying Resin Variability Using a Process Characterization Kit
This webinar illustrates a cation exchange chromatography process development workflow to assess the effect of ligand density variability on product quality and process performance using a Process Cha…
Article
Downstream Processing for Cell-Based Therapies
By Qasim A. Rafiq, Fernanda Masri
With increasing numbers of advanced therapies—including cell and gene therapies—entering early- and late-stage clinical development, significant focus has been …