Search results for " mass transfer"
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Trends in Single-use Bioreactors
Ang (Eppendorf): Most notable is the innovation of single-use bioreactors suitable for microbial fermentations, demanding in energy input as well as heat and mass transfer. Everyone is familiar with t…
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Evolution of the Monoclonal Antibody Purification Platform
The key benefits it offers are the elimination of diffusive pores and making the mass transfer of the protein to binding sites convective rather than diffusive. The use of convective transfer results …
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Right the First Time: Bioreactor Scale and Design Translation
This includes the hydrodynamic environment induced by the agitator and the mass transfer capability of the spargers at different gas flow rates. Cell culture processes need to operate in a design spac…
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Mapping a Route for Cell and Gene Therapy Process Development
While cell and gene therapies differ in many ways, some of the best practices for process development and validation are similar.
By Cynthia A. Challener
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Nurturing Knowledge from Disparate Data Streams
Leveraging vast quantities of analytical data requires digitalization and platform integration.
By Cynthia A. Challener
jijomathai/stock.Adobe.comAnalytical instrument…
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The Challenge of Disruptive Technologies in Bioprocessing
…chromatography resins with a differentiating range of hydrophobicity, resolution, high capacity, and mass transfer characteristics for increased throughput.
To address the challenge of how to …
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Challenges in Cell Harvesting Prompt Enhancements
Challenges in Cell Harvesting Prompt Enhancements
Higher cell titers and cell densities have posed a challenge to cell harvesting, a crucial step in biologics manufacturing.
By Feliza Mi…
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Adherent Cell Culture in Biopharmaceutical Applications: The Cell-Detachment Challenge
The necessity to detach cells from a culture substrate during cell harvesting remains one of the most challenging steps in a cell-culture process.
By Marcos Simon, Juan J. Giner-Casares
Cell…
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Applications of Surface Plasmon Resonance for Detection of Bispecific Antibody Activity
Surface plasmon resonance is helping define bispecific antibodies, the next-generation of biopharma therapeutics.
By Robert Karlsson
Abstract
Biotherapeutic antibodies are still the larg…
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Optimizing Cation-Exchange Chromatography with High-Throughput Process Development for mAb Purification
Even though the binding phase may be constrained to a certain residence time due to mass transfer limitations and a decrease in capacity at higher flow velocities, equilibration, wash, and elution can…