Search results for " cell-line"
Article
New Therapies Present Scaling Challenges
With allogenic cell therapies, a single batch of donor cells is used to produce large volumes of the product for many patients, a model similar to traditional mAbs, in which a single cell-line source …
Article
Optimized Process Efficiency in Upstream Manufacturing
Click here to learn how faster cell-line development, real-time analytics, and other approaches can be used to create a flexible, efficient, and cost-effective process.
Article
Science Focus Fuels Successful Process Development for Startups
For Krystal Biotech, which is developing gene therapies for skin diseases using a new vector for delivery, process development has involved cell-line engineering as well as determination of the optimu…
Article
Optimizing Late-Stage and Commercial Cell-Culture Processes
• Targeted integration cell-line development to obtain high productivity and consistent and stable parental cell lines.
• Efforts on continuous processing, which have been advertised for their …
Article
Impurity Testing of Biologic Drug Products
For non-therapeutic host cell proteins, cell-line specific ELISA are often used though mass spectrometry techniques can provide the discriminatory and quantification power required for these complex m…
Article
Platform Technologies Improve Protein Expression
…ans, and ultimately patients in need of novel medications,” notes Bjørn Voldborg, director of CHO cell-line development at the Novo Nordisk Foundation Center for Biosustainability.
Improving ef…
Article
Single-use Bioreactors Have Reached the Big Time
Cytiva has invested heavily in its process development capabilities to help optimize cell-line performance, cell-culture media and supplement consumption, and biologic quality in a continuous process.…
Article
Managing Biomanufacturing Capacity Expectations
…date volumes typically seen at larger facilities), the resulting products were also shown to enhance cell-line charge heterogeneity, proving that concentrated fed-batch could be associated with “both…
Article
Implementation of Raw Material Control Strategies in the Manufacture of Single-Use Bioprocessing Containers
The authors review efforts to limit polymer degradation without significantly impeding cell growth.
Jan 01, 2015
By Sara Ullsten, Shujian Yi, Jeffrey Carter, Eva Lindskog, Pokon Ganguli, Her…
Article
Biopharma Outsourcing Activities Update
Outsourcing activity remains strong and unlikely to abate, especially in more traditional areas.
Over the past 11 years, BioPlan’s annual report and survey of biopharmaceutical manufacturing ha…