Search results for "HIC"
Article
Process Chromatography: Continuous Optimization
Drug manufacturers are always seeking ways to improve the efficiency and productivity of chromatographic separations. Suppliers of chromatography resins are developing new resin chemistries and bindin…
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Tackling Analytical Method Development for ADCs
Their composition--a biologic linked to a small-molecule cytotoxic, which enables targeted delivery--also creates challenges for analytical method development, both for characterization and lot releas…
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Evolution of the Monoclonal Antibody Purification Platform
Hydrophobic-interaction chromatography (HIC) in bind and elute mode has been used to achieve further clearance of product-related impurities.
• Virus filtration step is the method of choice as…
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Top challenges in recombinant protein purification process development
Well, for recombinant proteins, you often don't have an affinity solution, an affinity chromatography solution that can be used, which is very different from mAbs, which do have a great affinity solut…
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Enhancing Resins Addresses Purification Concerns
The mRNA vaccines in particular are still rather new to the market, which is why no such platform processes seem to be in place.”
One common feature of all mRNA-based APIs is the poly(A) tai…
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Development and Future of Protein A Chromatography Technology: Q&A with Jonathan Royce, Business Leader Chromatography Resins, Cytiva
Several years ago, we started a development project to design and validate the next-generation protein A resin, MabSelect PrismA, which was just introduced to the market. Now, 1M NaOH can in fact be u…
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Protein Purification Troubleshooting Guide
Includes general tips and specific help for SEC, AC, IEX, and HIC*. Get practical advice on small changes and active choices that can significantly impact your purification results.
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Chromatography for the Diversified Antibody Pipeline
… Helding: The advantage of producing monoclonal antibodies is that we can apply platform processes which makes the development and manufacturing easy. As we shift to a diverse pipeline this may be di…
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Fundamentals of Hydrophobic Interaction Chromatography
This article explores the fundamentals and applications of hydrophobic interaction chromatography using Capto™ resins to increase productivity.
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Getting a Handle on Biopharma’s Most Critical Quality Attributes and Quality Control
Complexity—in particular, determining which product attributes are most crucial to product quality and patient safety—makes it challenging to apply quality-by-design (QbD) methods and process analytic…