Search results for " viral vectors"
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A Closer Look at Affinity Ligands
…phy matrices have been developed with high selectivity for purification of, for example, recombinant viral vectors for gene therapy applications.In one example, camelid single domain antibodies that …
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Commercial Production of Gene Therapies Using Suspension or Adherent Cell Lines
The most common viral vectors used in gene therapy are based on adeno-associated virus (AAV) and lentivirus. However, adenovirus and retrovirus are also of interest in this space (the latter being pri…
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Going Viral
How a new factory-in-a-box is helping scale up manufacturing of viral vector-based therapies to reach more patients.
Manufacturing viral vector-based therapies such as vaccines and gene…
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Addressing the Challenges in Downstream Processing Today and Tomorrow
…cines, antibody-drug conjugates, nonantibody protein scaffolds, PEGylated proteins and peptides, and viral vectors.
Some of the newer BioTx use nonmammalian expression systems such as yeast and …
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Process Development: 2020 Reflections and 2021 Possibilities
Spotlight on Vaccines and Viral Vectors
At the forefront of many minds in 2020 going into 2021 is vaccine development and manufacturing. Among the many vaccine challenges in relation to the urgenc…
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Scaling Up Novel Therapies
“Many processes rely on the culture of adherent cells for producing a range of biological molecules, including viral vaccines, viral vectors for gene therapy, and oncolytic viruses. Producing these th…
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Next Generation Process Chromatography
Next, we are obviously making the most of this technology being well-suited to the purification of larger entities such as viral vectors for use in gene therapy. We intend to launch both affinity and …
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Enhancing Resins Addresses Purification Concerns
What COVID-19 brings to the table
The COVID-19 vaccines comprise several possible and different modalities, such as messenger RNA (mRNA), attenuated viruses, viral vectors, proteins, and virus l…
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Lessons Learned Accelerate Vaccine Development
Redlich agrees, “Having a deep understanding of vaccine manufacturing technology--preferably platform technologies, whether for adeno viral vectors or bacterial vectors, is crucial for achieving rapid…
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Improving Upstream Predictability
Movement to continuous bioprocessing will have an impact on bioreactor technology, says Becheau, especially as upstream production processes for viral vectors become mature. She expects to see continu…