Search results for " chromatography column"

Article Making the Move to Continuous Chromatography
Making the Move to Continuous Chromatography Early adopters are benefiting from lower costs and increased productivity. By Cynthia A. Challener Tashatuvango/Shu…

Article Optimizing Resin Performance with Disposable Chromatography Solutions
The experts addressed how disposable chromatography columns can be used throughout the life of a campaign, the costs and benefits associated with using prepacked columns, the complexities of resin str…

Article Process Chromatography Selection for Downstream Processing Applications
BioPharm: What are some common chromatography column issues one might experience? How can these issues be addressed? Björkman (Cytiva): Some common chromatography column issues include: • Colu…

Article Improving Process-Scale Chromatography
The commercial-scale unit has up to eight chromatography columns in the single-use flow path and the ability to purify target biomolecules from bioreactors up to 2000 L in size within a 24-hour operat…

Article Evaluating the Use of Continuous Chromatography
Continuous processes continue to advance in bioprocessing. In downstream processing, continuous chromatography is gaining traction in the purification of protein therapeutics. As the biopharma…

Article Reducing Cross-Contamination Risks in Process Chromatography
The company is working with Amgen to test the performance of a custom-designed, 3D-printed chromatography column to determine if it can be used in Amgen’s R&D efforts to develop improved processes for…

Article A Look at the Affinity Chromatography Landscape
A Look at the Affinity Chromatography Landscape New ligands are being developed to meet the separation and purification needs of next-gen biologics. By Cynthia A. Challener …

Article Process Chromatography: Continuous Optimization
Improved resin chemistries and customized separation solutions are enabling more efficient separations. By Cynthia A. Challener Cell-culture and fermentation are high-…

Article Mechanistic Modeling of Preparative Ion-Exchange Chromatography
Figure 2: A typical setup of a bioreactor system model along with a chromatography column. The delay volumes are modeled as a chain of continuous stirred tank (CSTR) and dispersed plug flow (DPFR) rea…

Article HT Multi-Product Liquid Chromatography for Characterization of Monoclonal Antibodies
If used correctly, these new analytical methods can reduce analysis and product development time. ABSTRACT Monoclonal antibodies represent a significant portion of sales in the biopharma…

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