Search results for " serotype"
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Gene Therapies Push Viral Vector Production
By now, a wide variety of AAV serotypes have been studied, adds Kai Touw, technical lead at Batavia Biosciences, a Netherlands-based contract development and manufacturing organization (CDMO). Some of…
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Balancing AAVs Versus LLVs
The prevailing understanding is that serotypes bind to different, or have differential affinities to an array of primary cell surface glycoprotein receptors and secondary receptors.
Pharmace…
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A Look at the Affinity Chromatography Landscape
Baker points to ligands for AAV vector purification with both broad and specific serotype selectivities. “These developments have made the purification of certain vectors much more efficient and consi…
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How to optimize AAV capsid separation
In this free, interactive course you’ll learn how to tackle one of the key challenges in Adeno-associated virus (AAV) manufacturing–separating full and empty capsids in the polishing step. You’ll …
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Single-Use Technologies Prove Effective for Viral Vector Process Development
Even so, Sanderson observes that adherent bioreactors have a process advantage over suspension bioreactors for intracellular products such as those based on the AAV2 serotype, in which the attachment …
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How to develop a scalable rAAV process
We produce and purify several serotypes, optimizing each step along the way. The key for a successful process are high overall yields of full capsids with empty capsid reduction and efficient impurity…
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From cells to purified capsids: How to develop a scalable rAAV process
We produce and purify several serotypes, optimizing each step along the way. The key for a successful process is high overall yields of full capsids with empty capsid reduction and efficient impurity …
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Next Generation Process Chromatography
A toolbox of affinity ligands will be required long term to support the many different viral vector serotypes. The affinity story is definitely something we are heavily developing, and teamed up with …
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Scaling Up Novel Therapies
Viral vectors—for example, AAV serotypes for gene therapies—could benefit from this technology,” he says. “This would allow gene therapy developers to use some of the platform technology thinking that…