Search results for " scalable"
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Techniques for Improving Process Development for Exosome-Derived Therapeutics
Specifically, Codiak is investigating the delivery of nucleic acids and engineering exosomes that, when combined with a platform production process, can become exosome drug therapeutics that are scala…
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Single-use Bioreactors Have Reached the Big Time
Adds Adams: “single-use bioreactor technology has matured to the point where suppliers now offer large-scale, robust, well-characterized products that are reliable, scalable, and often preferred over …
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A deep dive into optimizing AAV capture and polishing to maximize both yield and purity
To meet these needs, Cytiva developed scalable capture and polishing chromatography steps for recombinant AAV (rAAV). The affinity capture step maximizes recovery and efficiently removes impurities.
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mRNA: The Messenger - mRNA Product Purification
Explore the mRNA universe with Cytiva.
Join us for part 4 of mRNA : the messenger, where we discuss key considerations for the purification of the mRNA product, including the various m…
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Recombinant Adeno-Associated Virus Type 5 Production Process
A scalable recombinant adeno-associated virus (rAAV) type 5 production process was developed using transfected HEK293 suspension cells.
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Cell culture process development for AAV vector production in suspension cells
Adaptation of HEK293 suspension cell line for transient transfection and scalable adeno-associated virus (AAV) production.
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Technology Innovations Improve Process Chromatography Performance
In this case, pressure is placed on the buffer train, so it is necessary to ensure that the buffer prep operation is efficient and scalable,” Deorkar states.
However, increasing the size of downst…
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Flexible Facilities for Viral Vector Manufacturing
Both options typically do not have scale limitations and thus would allow for a more scalable process.
The initial KUBio box for viral vector production was designed for a 200-L process scale, but…
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Mapping a Route for Cell and Gene Therapy Process Development
Reducing manufacturing costs, as well as development of scalable, automated manufacturing processes under closed systems that can reach the target quantities while maintaining the critical quality att…
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Single-Use for Downstream Chromatography: Benefit or Hindrance?
Single-use technology is gaining ground in downstream bioprocessing, but challenges stall further adoption.
By Feliza Mirasol
ARTMOIS/STOCK.ADOBE.COM
Biopharmaceutical manufactu…