Search results for " scalable" in Articles / App Notes
Article
A scalable single-use two-step plasmid purification process
The current global demand for biopharmaceuticals is over USD 300 billion, with an estimated growth of ≥ 12% annually. While MAb processes have become much more efficient, production of mRN…
Article
Successful Development of Scalable AAV Processes: Part 2 of 2
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In the second of a two-part series, Anki Magnusson, Staff Research Engineer, Protein and Viral Production, and Åsa Hagner-McWhirter, PhD, Senior Scientist, Bio…
Article
Insights and Strategies for Successful Development of Scalable AAV Processes: Part 2 of 2
part2
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In the second of a two-part series, Anki Magnusson, Staff Research Engineer, Protein and Viral Production, and Åsa Hagner…
Article
Process Economic Simulation for Scalable Production of Adenovirus
This application note discloses the process economic modelling of a modern start-to-finish adenovirus production process. The novel process was compared with a reference process in both stainless-st…
Article
Single-Use Technologies Prove Effective for Viral Vector Process Development
Developers are consequently turning to more scalable technologies with higher throughputs and economies of scale while reducing footprint, manual operations, and cost of goods compared to 2-D technolo…
Article
Maximum Output Starts with Optimized Upstream Processing
Furthermore, Chilima observes that by using scalable technologies that have representative scale-down models early in the process development, companies are able to evaluate the capacity needed early …
Article
Commercial Production of Gene Therapies Using Suspension or Adherent Cell Lines
At the same time, the production platform selected to manufacture clinical material must be scalable in order to enable the target capacity to be reached and promote cost-effectiveness. Adherent cell …
Article
Being Thorough When Transferring Technology
…ogics?
Moscariello and Young (CMC Biologics): Depth filtration and centrifugation are not always scalable for manufacturing operations. However, having both technologies is desirable based on the…
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Downstream Processing for Cell-Based Therapies
…- and late-stage clinical development, significant focus has been directed toward the development of scalable, robust manufacturing processes. Much of the research and development activity in the sec…
Article
Enhancing Resins Addresses Purification Concerns
“The key challenge for any process developer working on a downstream process is to develop a robust, scalable, and cost-efficient process to get to market in a short time,” adds Ihre. For more mature …