Search results for " electrophoresis"
Article
Elucidating Biosimilars Characterization
Glycans are traditionally analyzed using either liquid-phase separation techniques such as liquid chromatography or capillary electrophoresis with optical or fluorescence detection or mass spectrometr…
Article
The Importance of Process Intensification and PAT for Achieving Real-Time Release
It is likely that initial model PAT solutions that provide rapid results in an on-line setting, integrated with process control capabilities for more complex analyses such as capillary electrophoresis…
Article
Reimagining Affordable Biosimilars
Multi-attribute methodology (MAM), liquid chromatography (LC), and capillary electrophoresis coupling techniques allow simultaneous measurement of multiple product and process impurities in an automat…
Article
Moving PAT from Concept to Reality
…detection and monitoring, devices for on-line or at-line detection of adventitious agents, capillary electrophoresis and capillary isoelectric focusing-based microfluidics devices for real-time prot…
Article
Modeling the Degradation of mAb Therapeutics
Size-based monitoring tools such as SEC, DLS, mass spectrometry (MS), and sodium dodecyl sulfate–polyacrylamide gel electrophoresis (SDS–PAGE) are commonly used to detect fragmentation and identify th…
Article
Recent Advances in the Use of Exoglycosidases to Improve Structural Profiling of N-glycans from Biologic Drugs
Comparison of commercial preparations of common analytical glycosidases visualized by sodium dodecyl sulfate-polyacrylamide gel electrophoresis separation followed by staining. The empty lane for supp…
Article
Preclinical Evaluation of Product Related Impurities and Variants
Preclinical Evaluation of Product Related Impurities and Variants
The approaches for sample preparation of preclinical evaluation of safety and efficacy are addressed taking into consideration the s…
Article
Managing Residual Impurities During Downstream Processing
Methods include immunoassays, electrophoresis, Western blots, and chromatographic and proteomic techniques. The standard provides information on the assay development cycle, development and characteri…
Poster
Residual DNA analysis in influenza vaccine processing
However, these kits are developed mainly for purification of DNA fragments from gel electrophoresis or genomic DNA from tissues such as blood or cultured cells, and do not have recovery as a priority.…
Article
A Platform Approach for the Identity Testing of Multi-Component Cell-Culture Media
Data acquired from osmolality, glucose, and folic acid tests provides useful information for the specific identification of cell-culture media.
By Satish Mallya, Benjamin Lay, Lihong McAleer, Alexa…