Search results for " fed batch"
Article
Analytical Considerations for Successful Upstream Process Development with Spivey and Lane
Spivey and Lane
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Analytic considerations for upstream processing – covering Process Analytic Technology (PAT), time-savings versus off-line ana…
Article
Biopharmaceutical Process Development: 2018 Lessons and 2019 Predictions
The biopharmaceutical industry continues to expand in new and exciting ways. What might be in store for 2019, and what important lessons should process developers take from 2018? Here, we look back …
Article
Scaling Up Novel Therapies
“The upstream process is where you see major opportunity to intensify the process witheither intensified fed batch or continuous perfusion approaches that can be both scaled up and out,” says Peter Le…
Article
Commercial Production of Gene Therapies Using Suspension or Adherent Cell Lines
This article will explore the traditional path from the laboratory to the clinic and how the fixed-bed technology provides an alternative solution to meet commercial demands.
By Alex Chatel and …
Article
Using Digital Twins to Model Process Chromatography
Mechanistic models provide process understanding for developing robust manufacturing processes and for scale up and tech transfer.
By Jennifer Markarian
A digital twin is a model of a proces…
Webcast
Strategies and emerging technologies for mAb capture
In this webinar we will describe and evaluate different process intensification strategies for the mAb capture step. Strategies will depend on the mode of upstream operations (fed batch or perfusion…
Article
Strategies and Emerging Technologies for mAb Capture
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In this webinar, we will describe and evaluate different process intensification strategies for the monoclonal antibody (mAb) capture step. Strategies wi…
Article
Considerations for Optimizing Process Development
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Intensify your cell culture processes to keep pace with today’s industry and regulatory expectations.
Article
Performance of Single-Use Xcellerex™ XDR‑500 MO and XDR‑50 MO Stirred-Tank Fermentor Systems
This application note describes the performance of the XDR‑500 MO fermentor system in comparison with the XDR‑50 MO fermentor. Domain antibody production in E. coli was used as the model process. …
Article
Platform Approach Speeds Process Development
Figure 3: Normalized product concentrations (A) and viable cell concentrations (B) of a fed batch process performed at 100-L scale in single-use bioreactors before and after direct process transfer fr…