Search results for " AAV"
Article
Successful Development of Scalable AAV Processes: Part 2 of 2
Watch the Q&A interview >>
In the second of a two-part series, Anki Magnusson, Staff Research Engineer, Protein and Viral Production, and Åsa Hagner-McWhirter, PhD, Senior Scientist, Bio…
Article
Top Challenges to Overcome When Developing AAV Processes: Part 1 of 2
Watch the Q&A interview >>
In the first of a two-part series, Anki Magnusson, Staff Research Engineer, Protein and Viral Production, and Åsa Hagner-McWhirter, PhD, Senior Scientist…
Article
How to Optimize and Scale Up AAV Production
In this article from a roundtable discussion, four experts from academia and industry met to discuss challenges in refining and scaling up AAV production pipelines to meet the increasing demand for …
Article
Future-proof your AAV process with a complete producer cell line – just induce and grow
To deliver on the promise of AAV-based gene therapy for prevalent diseases, we need similar technology. The challenge is that multiple genetic elements – rep, helper, capsid, and gene of interest – mu…
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Gene Therapies Push Viral Vector Production
Of these, AAVs have gained much attention as a gene delivery vehicle and are being explored for their commerical viability. The commercial viability of other virus types also continues to be explored,…
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A Look at the Affinity Chromatography Landscape
Baker points to ligands for AAV vector purification with both broad and specific serotype selectivities. “These developments have made the purification of certain vectors much more efficient and consi…
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A Closer Look at Affinity Ligands
A new generation of vector serotype specific and non-specific affinity ligand chromatography resins are proving successful in capturing LV and AAV particles from cell-free media and promise the potent…
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Single-Use Technologies Prove Effective for Viral Vector Process Development
…ccines, recent data have shown that stainless steel can have a negative impact on the infectivity of AAV, which, reinforces the strategy of using single-use technologies, says Emmanuelle Cameau, tech…
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Scaling Up Novel Therapies
For example, a new collaboration (1) that involves Cytiva, Cobra Biologics, and UK’s Center for Process Innovation, is working on new ways to use fiber-based chromatography to improve AAV scale-up. Ot…
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Report from the 6th International HTPD Conference
Beyond mAbs: AAV and mRNA process development were discussed at HTPD 2023
Since the clinical pipeline is becoming more and more diversified, novel types of biomolecules have also become more in…