Search results for " cell growth"
Article
Tools for Continuous Bioprocessing Development
Typical usage of the FiberCell system involves seeding cells in the space outside of the fibers and pumping fresh media through the fibers to maintain a proper environment for cell growth (22). Since …
Article
Single-Use Technologies Prove Effective for Viral Vector Process Development
Cell factories have their own limitations, such as variable volumes and a lack of a sufficient gas exchange for optimum cell growth. For all of these systems, extensive manual procedures and open mani…
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Concentrating Feed—an Applicable Approach to Improve Antibody Production
Although higher concentrations of feed media could be obtained by raising pH, there was an optimal pH of feed media in which cell growth and antibody production were not adversely affected. The additi…
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Overview of a scale-up of a cell-based influenza virus production process using ReadyToProcess equipment
The cell growth rate was shown to be similar in both the 10 L and 50 L cultures in three consecutive batches (Fig 3).
In the 50 L cultures, cells were grown to a cell density of approximately 2 × …
Article
Gene Therapies Push Viral Vector Production
Gene Therapies Push Viral Vector Production
Viral vectors show promise as a delivery mechanism for gene therapy, but which virus types are commercially viable?
By Feliza Miraso…
Article
Platform Approach Speeds Process Development
These packages aim to improve cell growth, product formation, productivity, and customize product quality by systematically optimizing process and media factors.
For the production of new biologic…
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Platform Technologies Improve Protein Expression
Understanding and tools for better engineering the overall metabolism of host cells with the capability to balance protein generation in several different phases with cell growth and survival will rem…
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Host-Cell Protein Measurement and Control
During the recombinant protein production, host cells also coproduce proteins related to the normal cell functions such as cell growth, proliferation, survival, gene transcription, protein synthesis, …
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Unifying Continuous Biomanufacturing Operations
The success of a truly integrated continuous processing platform relies on the collaborative efforts of upstream and downstream specialists.
By Randi Hernandez
When human cells travel throug…
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Antibody Production in Microbial Hosts
The authors review the status of expression of antibodies in microbial hosts and present the recent advances in the production of aglycosylated antibodies in bacteria.
By Anurag S. Rathore, Jyot…