Search results for " efficiency"
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Process Development: 2020 Reflections and 2021 Possibilities
Improving Process Development Efficiency
The COVID-19 pandemic has highlighted just how desperately effective approaches to improve efficiency in process development are needed for both developers…
Article
Best Practices for Selecting a Top-Quality Cell Line
…—with all product quality attributes consistent with the desired profile—with high manufacturing efficiency, according to Ian Collins, senior director of process development at Catalent. “A high-qual…
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A Look at the Affinity Chromatography Landscape
A Look at the Affinity Chromatography Landscape
New ligands are being developed to meet the separation and purification needs of next-gen biologics.
By Cynthia A. Challener
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Development of Purification for Challenging Fc-Fusion Proteins
Development of Purification for Challenging Fc-Fusion Proteins
This study outlines methods for an alternative protein-polishing process for challenging proteins.
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Impact of Media Components on CQAs of Monoclonal Antibodies
Hydrocortisone improves the cloning efficiency of the glial cells and fibroblasts (2). Along with hydrocortisone and prolactin, various combinations of estrogen, androgens, and progesterone are necess…
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Mechanistic Modeling of Preparative Ion-Exchange Chromatography
By Anurag Rathore, Vijesh Kumar
Among the various downstream processing unit operations that are used for purification of biotech products, chromatography is uniquely capable of providing resolu…
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Designing a Biomanufacturing Facility Incorporating Single-Use Technologies
The final yield here is determined by the product titer of the production bioreactor, combined with the efficiency of the downstream purification steps, both of which will be driven by the details of …
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CMOs Continue to Improve Overall Biomanufacturing Performance
By Eric Langer
Biomanufacturing efficiency is on everyone’s minds, being the single most important area of focus for global bioprocessing. And contract manufacturing organizations (CMOs) are on th…
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Modular Manufacturing Platforms for Biologics
…puts, and transformations—is the best way to allow for customization while maintaining quality and efficiency.” As Emel notes, different modular approaches will work for different manufacturers, espe…
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Fermentation for the Future
Drivers of new technology development in microbial fermentation are similar to those for cell-culture processes and include reducing costs, increasing efficiency/productivity, and enhancing quality, s…