Search results for "Recovery"
Article
Establishing Acceptance Criteria for Analytical Methods
Traditional measures of analytical goodness include the following:
• % coefficient of variation (CV) = (repeatability/mean)*100
• % recovery = (measured concentration/standard concentration)*100
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Article
PDA's Technical Report for Biotech Cleaning Validation
Sampling recovery studies for biotech cleaning validation are not different in principle from sampling recovery studies in nonbiotech cleaning validation. However, residues used for spiking surfaces f…
Article
Gene Therapies Push Viral Vector Production
…and for AAV specifically, improve ratio of full versus empty capsids; as well as improve downstream recovery (currently at best 30%, new nanofiber technologies coupled with next generation of ligands…
Article
Evolution of the Monoclonal Antibody Purification Platform
Load capacity (>1500 g/L) may be achievable with > 95% product recovery and robust process performance.
Monoclonal antibodies expressed in yeast
While mammalian cells (e.g., such …
Article
Virus and exosome purification: harness core bead technology
Using core bead technology to fine tune impurity removal and maximize recovery of
large entities.
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Article
Evaluation of Fibro PrismA for Scalable Single-Use mAb Purification
The team assessed scalability from lab- to process-scale units, tracking pressure drop, step recovery, purity, and eluate volumes across multiple cycles.
Article
Technology Innovations Improve Process Chromatography Performance
“In downstream processing, the ultimate goal for biopharma manufacturers is to improve recovery and reduce the cost per gram of protein produced. Currently, over 60% of the cost to produce a new biolo…
Article
A Look at the Affinity Chromatography Landscape
A new, sulfated cellulose affinity membrane specifically designed by Sartorius for virus capture provides maximum virus access with increased selectivity and product recovery. It is useful for the cap…
Poster
Fast Trak Services: a collaborative project to accelerate downstream biosimilar process development
Consequently, low product recovery and purity were obtained in the first-generation purification process. In addition, the purification protocols were poorly suited for manufacturing scale.
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Article
Downstream Processing for Cell-Based Therapies
Using TFF and EBC, Cunha and colleagues showed high protein clearance (98%), high recovery of viable hMSCs (70%) with no impact on cell viability (95%) or other CQAs (morphology, immunophenotype, prol…