Search results for " small-scale" in Articles / App Notes
Article
Use of Multivariate Data Analysis in Bioprocessing
Figure 2: Multivariate data analysis and modeling of representative data from small-scale (2 L) and large-scale (2000 L) batches of a cell-culture process. Adapted with modification from Ref. 21.
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Article
Viral Clearance Challenges in Bioprocessing
Viral clearance is assessed in small-scale tests, and regulatory guidance documents provide a general framework for how these tests should be performed (1). Even with guidance, however, demonstrating …
Article
Essentials in Establishing and Using Design Space
Verification runs for small-scale and at-scale processing conditions are essential for model verification. Rescaling the model for the full-scale run conditions may need to be done.
Product …
Article
Quality by design for biotechnology products—part 1
A risk assessment should be performed to identify the process parameters that should be characterized using small-scale models and tools such as design of experiments (DoE). One approach commonly used…
Article
Report from the 6th International HTPD Conference
In the 2nd session Manoj Ganesh from Regeneron highlighted how his team is using same or similar HTPD approaches to also support manufacturing with troubleshooting and accelerating small-scale investi…
Article
A better way to purify small drug volumes
Viral vectors: demand is high and getting higher. But purifying viral vectors with methods optimized for other products can affect yield, purity, and cross-contamination.
How does the …
Article
Enhancing Resins Addresses Purification Concerns
Meanwhile, precipitation, digestion, ultra or microfiltration, and membrane capture can all be used at the lab scale to efficiently test small-scale samples, notes Deorkar. However, scale up of these …
Article
Improving the Oligonucleotide Synthesis Experience
Addressing this challenge was one of Cytiva’s main goals when we set out to develop a system for small-scale synthesis and process development.
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Article
Maximum Output Starts with Optimized Upstream Processing
“Efforts have targeted the development of new expression technologies, parallel tracking of activities that are not on the critical path, and implementing high-throughput, small-scale technologies,” c…
Article
Gene Therapies Push Viral Vector Production
“We must bring robust, scalable, industrialized manufacturing processes as fast as possible (less manual and more automated processes) and GMP solutions for both small-scale and large-scale production…