Search results for " antibody-drug conjugate"

Article Tackling Analytical Method Development for ADCs
Feb 01, 2015 By Cynthia Challener, PhD BioPharm International Volume 28, Issue 2 The targeted therapy possible with antibody-drug conjugates (ADCs) makes them an attractive class of …

Article ADC Development Robust Despite Lackluster Performance
Takeda Pharmaceutical, “Mersana Therapeutics and Takeda Expand Partnership to Advance Development of Fleximer Antibody-Drug Conjugates and XMT-1522 [15],” Press Release (Feb. 3, 2016). 15. BioPh…

Article Addressing the Challenges in Downstream Processing Today and Tomorrow
A broad range of alternative BioTx modalities have obtained regulatory approval and are currently in clinical trials (17–21) including antibody fragments, single-domain mAbs, Fc-fusions, vaccines, ant…

Article Single-Domain Antibodies for Brain Targeting
Single-domain antibodies are emerging as credible alternatives due to their target specificity, high affinity, and cost-effective recombinant production. Smaller recombinant antibody fragments a…

Article Being Thorough When Transferring Technology
BioPharm: Are there specific challenges for the tech transfer of antibody-drug conjugates (ADCs)? Monoclonal antibodies? Cell therapies? Moscariello and Young (CMC Biologics): The major challenges…

Article SEC in the Modern Downstream Purification Process
The separations of antibody-drug conjugates from the unbound payload molecule are also amenable to SEC. In these types of applications, the payload molecule (usually a cytotoxin) is added in a signifi…

Article Extractables in Single-Use Systems Used in ADC Manufacturing, Part 2
We performed extractables studies on single-use chromatography and tangential flow filtration systems using common solvents in ADC manufacturing, DMA and DMSO. The low levels of extractables f…

Article Exploring the world of antibodies: mAbs, Fabs, dAbs, and bsAbs
There is a vast array of antibody variants, including multispecific (msAb), bispecific antibodies (bsAb), antibody fragments (Fab, dAb, scFv), and antibody-drug conjugates (ADC). But with this…

Article Fundamentals of hydrophobic interaction chromatography
… * recombinant proteins and peptides  * monoclonal antibodies (mAbs), bispecific mAbs and antibody-drug conjugates (ADC) * mRNA * plasmid  New to HIC? Browse this HIC resource l…

Article Trends in Outsourcing of Bioprocess Development
Growing numbers of conventional recombinant proteins and monoclonal antibodies, as well as next-generation molecules such as multispecifics, antibody-drug conjugates, and cell and gene therapies, are …

Next Page