Search results for " Mabs" in Articles / App Notes
Article
Developing a HIC polishing step for removal of mAb aggregates
This article describes the development of a flow-through (FT) polishing step using hydrophobic interaction chromatography (HIC) to remove mAb aggregates.
It includes:
- The use of HTPD plate…
Article
Assessing leachables risk over a complete single-use, mAb process
Single-use systems (SUS) in biopharmaceutical manufacturing give advantages such as improved flexibility and plant efficiency, but also raise concern for compounds leaching from the pol…
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Get to know: mAb variants - eLearning
The diversity of antibody variants in the biotherapeutics pipeline are increasing with a growing interest for molecules like antibody fragments and bispecific antibodies (bsAbs). Cytiva has pu…
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Developing a Closed, Connected Single-Use mAb Purification Process
In the Protein A step, Fibro PrismA is compared with MabSelect PrismA regarding process time, recovery, and purification performance.
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Speeding Up mAb Purification Using Fiber-based Technology
Learn how to automate high throughput monoclonal antibody (mAb) purification and improve throughput significantly using fiber-based chromatography.
With purification cycles in minutes rather th…
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Factors Which Impact mAb Process Scale-Up
Thinking about your mAb scale-up processes early on can help avoid common pitfalls. Fast Trak™ scientists discuss factors that can influence a successful scale-up outcome.
Article
Exotoxin Clearance from mAb Samples in a Two-Step Chromatography Process
A heat-stable exotoxin can remain as a contaminant of a drug substance throughout the whole manufacturing process, with the risk of adversely affecting patients’ health. One such toxin is cereulide …
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Tools and Solutions for Separation of Charged mAb Variants
A biosimilar is an almost identical version of an originator product. To attain regulatory approval, a comparable quality to the reference product in terms of efficacy, purity, and safety should be …
Article
Technical and Process Economical Aspects of Using Capto™ Q and ReadyToProcess™Adsorber Q in mAb Polishing
Increasing product titers in upstream cell culture processes pose challenges to downstream purification processes. For efficient operations, downstream purification needs to be able to handle high p…
Article
Exploring the world of antibodies: mAbs, Fabs, dAbs, and bsAbs
Developing purification processes for antibody variants is not always straightforward and the platform approaches conveniently used for many traditional mAbs cannot be used.
Learn more about develo…