Search results for " screening" in Articles / App Notes
Article
Real-Time Characterization of Biotherapeutics and Comparability of Biosimilars
Therefore, SPR imaging systems without any labeling requirements are more suitable for high-throughput screening (HTS), particularly in drug discovery, than any other optics-based detection techniques…
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Automated Concentration and Diafiltration of Multiple siRNA Samples
The generation of many variants as candidates requires robust processes for screening to aid in selecting the optimum siRNA candidate. Automation of the production and screening processes has the inhe…
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Optimizing Cation-Exchange Chromatography with High-Throughput Process Development for mAb Purification
Objectives such as screening, optimization, and robustness testing are set before the studies begin. Data generated by DoE can be used to create models that can apply statistics to predict future resp…
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Top Tips for Successful Development of Antibody Chromatography Processes
So again, you can choose just a few selected resins that really address the challenge, instead of screening a large array of resins and hoping to find one that will work.
Jeanne Linke Northr…
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Report from the 6th International HTPD Conference
HTPD was mainly limited to 96-well plates filled with chromatography resins used for resin selection and initial screening of running conditions. Since then, HTPD in chromatography applications has be…
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Reimagining Affordable Biosimilars
Nano differential scanning fluorimetry (nano-DSF) has emerged as a high throughput platform for screening biotherapeutic formulations. Light scattering tools permit label-free size characterization, t…
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Ensuring Viral Safety of Viral Vaccines and Vectors
Speciesspecific retrovirus screening also exists.
In addition to screening the cell lines, master virus seed stock (MVSS) must also be screened fully to detect adventitious bacteria, fungi, myc…
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Modeling and Miniaturization: Key Topics at Successful HTPD Conference
HTPD was mainly limited to 96-well plates filled with chromatography resins used for resin selection and initial screening of running condition. Since then, HTPD in chromatography applications has bee…
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A Risk-Based Genetic Characterization Strategy for Recombinant CHO Cell Lines Used for Clinical and Commercial Applications
This early screening approach has identified cryptic aberrant splice sites in multiple therapeutic candidates including monoclonal antibodies, bispecific antibodies, and fusion proteins, therefore pre…
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Using Quality by Design to Develop Robust Chromatographic Methods
If structures are known, then the experimental screening strategy may be supplemented by the information to be gleaned from a Log(P) vs. pH plot (P is the octanol water distribution coefficient of all…