Search results for " scale-up"
Article
Unifying Continuous Biomanufacturing Operations
In the future, manufacturers will still have to identify optimal cycle time; weigh the risk of scale-up and explore how to construct continuous models that could eliminate scale-up altogether; test th…
Article
Generating a Fully Processed Antibody
In this article, the authors outline cell-line development and process scale-up for an antibody program in which the antibody requires additional processing by a site-specific enzyme for correct funct…
Article
Platform Approach Speeds Process Development
The implementation of disposable systems with diverse scales creates additional challenges in scale-up and scale-down because more systems and scales have to fit together with respect to process perfo…
Article
Lessons Learned Accelerate Vaccine Development
This achievement was made possible through the simultaneous refurbishment of an existing production facility and the technology transfer, optimization, and scale-up of the bioprocess combined with tre…
Article
Single-Use Technologies Prove Effective for Viral Vector Process Development
“When scaling up, it can sometimes be challenging to apply the correct scale-up strategy to get reproductive and scalable results, whatever the platform chosen. This difficulty can lead to a lower tit…
Article
Genetic Vaccine Platforms Demonstrate Their Potential
Such low doses require smaller facilities, which can be equipped with single-use (SU) technology, resulting in a faster scale-up and facility implementation.” Similarly, viral vaccines can be produced…
Article
The Evolving Role of Starting Materials in Cell and Gene Therapy
As new products start emerging onto the scale-up and marketing stage, manufacturing and supply companies are actively building the expertise and infrastructure necessary for commercial success.
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Poster
Scalable Continuous Chromatography Process for Enhanced Efficiency in Biomanufacturing
…tiva, we use two case studies to demonstrate that PCC is a robust and scalable technology: a 50-fold scale-up of a three-column PCC (3C PCC) mAb capture step within the lab-scale ÄKTA™ pcc syste…
Article
A Plastic Pipeline for Commercial Bioprocessing?
All product types evaluated in the survey—except sampling systems—are used less for commercial production than R&D, process development, and scale-up/ clinical production phases. Disposable chromatog…
Poster
Adenovirus production in a single-use stirring tank bioreactor system
However, scale-up using these techniques is complicated and limited by the surface available for cell growth. One alternative is to scale up the production on microcarriers. Another solution is to us…