Search results for " scale-up" in Articles / App Notes
Article
Single-Use Technologies Prove Effective for Viral Vector Process Development
“When scaling up, it can sometimes be challenging to apply the correct scale-up strategy to get reproductive and scalable results, whatever the platform chosen. This difficulty can lead to a lower tit…
Article
Genetic Vaccine Platforms Demonstrate Their Potential
Such low doses require smaller facilities, which can be equipped with single-use (SU) technology, resulting in a faster scale-up and facility implementation.” Similarly, viral vaccines can be produced…
Article
The Evolving Role of Starting Materials in Cell and Gene Therapy
As new products start emerging onto the scale-up and marketing stage, manufacturing and supply companies are actively building the expertise and infrastructure necessary for commercial success.
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Article
A Plastic Pipeline for Commercial Bioprocessing?
All product types evaluated in the survey—except sampling systems—are used less for commercial production than R&D, process development, and scale-up/ clinical production phases. Disposable chromatog…
Article
Trends in Downstream Bioprocessing
…e developers harboring regulatory concerns that hold them back from using newer solutions or process scale-up.
Chromatography column issues are showing a trend for decreasing “significant” or “se…
Article
The Development and Application of a Monoclonal Antibody Purification Platform
During scale-up, we noted that effective filtration required a much larger membrane area than was feasible, so we introduced a continuous flow centrifugation process, followed by depth filtration to m…
Article
The Lifecycle Change of Process Validation and Analytical Testing
…ds will not only support a robust commercial manufacturing process but can also reduce the burden of scale-up and technology transfer, thereby supporting product-divestment initiatives. The implement…
Article
Register to the Chromatography + Filtration Virtual Summit 2024
Explore the latest advancements in process development and scale-up
5-7 March, 2024 - 15:00 - 18:00 CET all 3 days
Join Cytiva Chromatography and filtration summit online to lear…
Article
Digitalization: The Route to Biopharma 4.0
Scientific knowledge comprises process development and validation, whereas technical know-how involves process definition and scale-up for commercial production. Multiple organizations need to collabo…
Article
Using Digital Twins to Model Process Chromatography
…cs, considering the small operating window at manufacturing scale and prohibitive expense of testing scale-up conditions. Models are typically calibrated using lab-scale data for material and cost ef…