Search results for " scale-down"
Article
Automation Trend in Fill/Finish Reduces Contamination Risk
…outsourcing to contract manufacturing organizations, further innovation for fill/finish equipment, a scale-down of isolator units and automation, potent compound handling, and more accurate filling f…
Article
Using Single-Use Technologies in Downstream Processing
Systems can be designed, tested (with good scale-down models), and implemented fairly quickly without the need for procuring stainless-steel parts or developing related cleaning cycles.
Challenges…
Article
Pharma Investments Reflect Key Industry Trends
Increasing access to single-use technologies for biologics production is further enabling the scale-down of manufacturing facilities, because such systems provide flexibility and enable companies to q…
Article
QbD and PAT in Upstream and Downstream Processing
While scale-down models combined with screening and design space DOEs can be used to understand cell expansion and the cell-production bioreactor processes, full purification can be time consuming and…
Article
Quality by design for biotechnology products—part 1
A PhRMA Working Group's advice on applying QbD to biotech.
By Taruna Arora, Roger Greene, Jennifer Mercer, Paul Tsang, Meg Casais, Stuart Feldman, Jutta Look, Tony Lubiniecki, Joseph Mezzatesta,…