Search results for "fermentor"
Article
E. coli growth and Dab expression in single-use and stainless steel fermentors
coli domain antibody (Dab) production process developed for a stainless steel fermentor. Cell growth,
cell density, and Dab expression levels were assessed and compared between the two production…
Article
Performance of Single-Use Xcellerex™ XDR‑500 MO and XDR‑50 MO Stirred-Tank Fermentor Systems
This application note describes the performance of the XDR‑500 MO fermentor system in comparison with the XDR‑50 MO fermentor. Domain antibody production in E. coli was used as the model process. …
Article
Stirring up the fermentation game
XDR-50 MO fermentor vessel and I/O cabinet
Introduction
The adoption of single-use technology by biomanufacturers using microbial systems has been inhibited by the lack of single-use …
Article
Scaling Up an E. coli Upstream Process for Plasmid DNA Production — from 2.5 to 160 L scale Fermenters
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This article summarizes the results of Escherichia coli growth performance for plasmid production in a 5 L glass fermentor, which was scaled up to 80 and 160 L scale in Xcellerex™ X…
Article
Scaling Up Novel Therapies
Scaling Up Novel Therapies
Platform processes have improved monoclonal antibody scale-up. Can they do the same for personalized therapies?
By Agnes S…
Article
Industry Adoption of Single-Use Systems Remains Low
“We have also launched a high-performance single-use microbial fermentor at the 500-L scale. In addition, we have also launched a single-use ÄKTA ReadyFlux ultrafiltration/defiltration system,” h…
Article
Determining Criticality, Part Two: DoE and Data-Driven Criticality
Because of the cost involved or availability of API, it is not possible to perform all experimental studies at commercial scale (such as with fermentors of 5000 to 25,000 L), hence, most biotech proce…