March 26, 2020

Manufacturing of Vaccines and Viral Vectors


With the pandemic outbreak of COVID-19, there is intense focus on developing a vaccine. However, the challenge not only lies in developing a vaccine but also in the ability to scale up the manufacturing process.

In this article, general guidelines for scaling up a viral vector and virus manufacturing processes are discussed. The case study is based on adenovirus and the results show a cost-efficient production at all investigated scales and scenarios, making it feasible for industrial production of adenovirus.

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Tags: scale up, adenovirus, viral vector manufacturing, vaccine manufacturing, vaccines