Virus Production in Single-Use Bioreactor Systems …
August 10, 2017 - Ann-Christin Magnusson, Eva Blanck, Margareta Berg… Since the 1980s, microcarriers have been used to provide growth support for adherent cells in vaccine biomanufacturing processes at scale…

Mixing and Temperature Characterization of Single-…
August 10, 2017 - Andreas Andersson, Karin Sjöberg Gällnö, Annika… Single-use mixing systems are widely used in biomanufacturing due to the many advantages that come with disposables, including reduced cr…

A downstream process for purification of Interfero…
December 3, 2014 - Sara Grönlund, Kjell Eriksson, Jamil Shanagar, Ch… The focus of this poster is on the development of the chromatography steps for a biosimilar molecule, interferon α-2a, expressed in E.…

Buffer plate preparation using ÄKTA™ avant syst…
October 29, 2014 - Susanne Westin, Gustav Rodrigo, and Enrique Carred… Manual buffer preparation for high-throughput process development (HTPD) requires a lot of effort as the number of different buffer condit…

Rapid screening of antibody aggregates and protein…
February 23, 2012 - Inger Salomonson, Jinyu Zou, Marianne Carlsson, An… Purification of antibodies often generates dimers and higher aggregated forms and during optimization of purification protocols, many samp…

Propagation of influenza virus in Vero cells using…
January 18, 2012 - Ann-Christin Magnusson, Therese Lundström, *Chris… The use of cell culture-based Live Attenuated Influenza Vaccines (LAIV) is seen as one way to secure a rapid supply of a large number of i…

Process development for cell-based influenza virus
January 5, 2012 - Hans Blom, Mia Bennemo, Karolina Busson, Camilla E… Influenza virus for vaccines is traditionally produced by infection of fertilized hen eggs. This is labor intensive and requires large fac…

A complete single-use manufacturing process of mon…
December 28, 2011 - Jakob Liderfelt, Janne Simola, Annika Forss, Gusta… This presentation describes a monoclonal antibody process that was run in pilot-scale. The process is based on technology suitable for fle…

In-line buffer conditioning for biopharmaceutical…
December 14, 2011 - Enrique Carredano, Tomas M. Karlsson, Roger Nordbe… Buffer preparation and handling is a major challenge in industrial biopharmaceutical production. There is a need to decrease costs in labo…

Critical aspects for mixing of stratified solution…
December 5, 2011 - Sebastian Rothe(1), Kieron Walsh(2), Wolfgang Hohe… With increasing use of single-use, disposable fluid processing systems, concerns for mixing arise in processes such as protein concentrati…

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