Search results for " Aggregate removal"

Article Challenges of Protein Aggregation During Purification
Careful selection of downstream processing conditions is a must. Sep 1, 2014 By: Cynthia Challener, PhD BioPharm International Volume 27, Issue 9, pp. 32-35  Removal of protein a…

Article Developing a mAb aggregate removal step by high throughput process development
High throughput process development allows rapid screening of chromatographic parameters. By Gustav Rodrigo and Kristina Nilsson-Välimaa ABSTRACT This article presents a case study ill…

Article What If You Could Remove Your Antibody Aggregates Already in the Protein A Step?
Register for this free, online webinar >> In this study, the potential of Protein A chromatography to separate antibody monomer from HMW species was investigated. A design of experiments approach…

Article Bioterminology: A Guide to the Biopharmaceutical Lexicon
Bioterminology: A Guide to the Biopharmaceutical Lexicon This lexicon was generated by the editors of BioPharm International magazine. Please feel free to email your suggestions for terms that s…

Article Polishing of Monoclonal Antibodies using Capto™ MMC ImpRes in Bind and Elute Mode
In order to fine-tune the protein/ligand interaction for optimal aggregate removal, the ligand density of Capto MMC ImpRes has been reduced significantly (25 to 39 μmol/mL) compared to Capto MMC (70 t…

Article Evolution of the Monoclonal Antibody Purification Platform
The authors discuss the evolution of the purification platform for manufacturing of mAb therapeutics. Monoclonal antibodies (mAb) increasingly form the majority share of the product pipeline…

Article Viral Clearance Challenges in Bioprocessing
Challenges remain for virus removal and validation. Nov 1, 2014 By: Cynthia Challener, PhD BioPharm International Volume 11, Issue 27, pp. 42-44 Removal and inactivation of adventitio…

Article Polishing of monoclonal antibodies using Capto adhere ImpRes in bind and elute mode
This application note describes a study where the binding capacity for MAbs and the efficiency in the clearance of impurities using Capto adhere ImpRes in bind/elute (B/E) mode was evaluated. For a …

Article Mixed-Mode Chromatography in Downstream Process Development
Antibody aggregate removal by hydroxyapatite chromatography. Curr Pharm Biotechnol. 2009;10:440–6. 10. Siouffi AM, Phan-Tan-Luu R. Optimization methods in chromatography and capillary electrophore…

Article Ensuring Viral Safety of Viral Vaccines and Vectors
Ensuring Viral Safety of Viral Vaccines and Vectors Viral vaccines and viral vectors used in biotherapeutic applications carry the risk of microbial contamination, which must be addressed. …

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