Search results for " purity"

Article Combine Chromatography Techniques: Get the Right Purity/Yield of Protein
This attractive wall poster shows you how to effectively combine techniques and succeed in your protein purification.    Order now for free  

Webcast Modernizing legacy vaccine processes to improve productivity and purity
Traditionally, the production of meningococcal A, C, W, Y vaccine has involved the use of phenol to rid the sample of protein material. Since the use of phenol is no longer acceptable, GE developed …

Article Developing a mAb aggregate removal step by high throughput process development
The use of the 96-well plate format enabled the efficient screening of three different media and optimization of chromatographic parameters to maximize yield at the desired purity level. Biopharmace…

Article High-throughput process development and scale-up of an intermediate purification step for recombinant insulin
Finally, the method was scaled up, first 40-fold and then 400-fold, with both purity and recovery exceeding 90%. This figure is a good basis for achieving the required purity (98% or more) in a follow…

Article Using Quality by Design to Develop Robust Chromatographic Methods
The following discussion outlines ATPs for a combined assay and purity method for a real-life drug substance, referred to henceforth as examplain hydrochloride (HCl): • Assay: The procedure must b…

Article Bioterminology: A Guide to the Biopharmaceutical Lexicon
A biosimilar may differ in its purity/impurity profile, and its potency may differ in a definable way. (See also biogeneric, follow-on biological)  biotechnology The industrial use of living thin…

Article Impurity Testing of Biologic Drug Products
In this roundtable discussion, industry experts share insights on the various methods used for purity and impurity analysis of therapeutic proteins. Method development and validation B…

Article The Development and Application of a Monoclonal Antibody Purification Platform
The platform was developed to maximize the efficiency of the purification process and product purity while minimizing the development time for early-phase therapeutic antibodies. The success of this p…

Article Downstream scale-up purification of influenza virus using ReadyToProcess equipment
Total process time for the downstream purification was 3 days and the overall scale-up process resulted in production of influenza virus with the same yield and purity as obtained in the laboratory sc…

Article Tips for High Resolution Ion Exchange Chromatography to Obtain a Pure Protein
The better the separation between peaks, the higher the purity of the proteins that will be collected.  Read the full article and get tips and tricks on how to obtain well-separated chromatogram pe…

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