Search results for "mRNA manufacturing scalability"

Article Maximum Output Starts with Optimized Upstream Processing
By Cynthia A. Challener Biopharmaceutical companies and contract manufacturers respond to changing demand dynamics for upstream bioprocessing capacity. Significant growth in the develo…

Article Genetic Vaccine Platforms Demonstrate Their Potential
In a pandemic, genetic vaccines offer several advantages over traditional approaches. By Cynthia A. Challener For a vaccine to be effective, the components of the disease o…

Article Gene Therapies Push Viral Vector Production
Gene Therapies Push Viral Vector Production Viral vectors show promise as a delivery mechanism for gene therapy, but which virus types are commercially viable? By Feliza Miraso…

Article Top Process Development Trends for 2021 and a Look into 2022
The COVID-19 pandemic continues to shape bioprocess development trends, and many lessons have been learned from industry’s response to and preparedness for dealing with a public health crisis. Howev…

Article Enhancing Resins Addresses Purification Concerns
Christoph Burgstedt/Stock.Adobe.com Enhancement of resin technology can improve the ability of chromatography to purify the growing landscape of increasingly complex biomolecu…

Article mRNA: The Messenger - mRNA Product Purification
Explore the mRNA universe with Cytiva. Join us for part 4 of mRNA : the messenger, where we discuss key considerations for the purification of the mRNA product, including the various m…

Article Platform Technologies Improve Protein Expression
Platform technologies facilitate development and accelerate commercialization of protein therapeutics. By Cynthia A. Challener    Speed to market is essential in the biopharmaceutica…

Article mRNA: The messenger - LNP formulation
Explore the mRNA universe with Cytiva. Join us for part 5 of mRNA: the messenger, where we discuss key considerations for the formulation of lipid nanoparticles (LNPs) for mRNA drug d…

Article Concentrating Feed—an Applicable Approach to Improve Antibody Production
In this study, the authors evaluated different approaches to prepare highly concentrated feed media for fed-batch Chinese hamster ovary cell culture. By raising the pH or by adding surfactants, the fe…

Article Techniques for Improving Process Development for Exosome-Derived Therapeutics
An interview with Aaron Noyes, Head of Downstream Processing at Codiak BioSciences Some therapeutic targets have long frustrated drug developers hoping to crack the code of mitigating un…