Search results for "bioproduction" in Articles / App Notes
Article
A Risk-Based Genetic Characterization Strategy for Recombinant CHO Cell Lines Used for Clinical and Commercial Applications
The authors describe the ways in which manufacturers can mitigate the risks related to the integrity of recombinant transgenes expressed in CHO cells.
By Luhong He, Christopher Frye
Abstract
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Article
Design and Qualification of Single-Use Systems
The author provides a review of the concepts of design and qualification that apply to single-use systems.
By Jerold M. Martin
Single-use technologies (SUT) have made significant inroads in …
Article
Quality by design for biotechnology products—part 1
A PhRMA Working Group's advice on applying QbD to biotech.
By Taruna Arora, Roger Greene, Jennifer Mercer, Paul Tsang, Meg Casais, Stuart Feldman, Jutta Look, Tony Lubiniecki, Joseph Mezzatesta,…
Article
Single-Use Technologies Prove Effective for Viral Vector Process Development
Residual activated trypsin can also inactivate many viral vectors,” says to Natraj Ram, vice-president of innovation in Thermo Fisher Scientific’s BioProduction business.
Adherent processes, Sande…
Article
Sanitization Opportunities for Protein A Resins
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Bacterial endospores present a challenge in bioproduction due to their resistance to common sanitization procedures using high concentrations of NaOH. Several protein-b…
Article
Do You Need Access to a Bioprocess Lab to Test Your Technical or Digital Innovation?
In the Testa Challenge, we invite projects and companies from the technology, digital, and data segments to integrate, test, and verify their innovation within a sponsored bioproduction workflow provi…
Article
Gene Therapies Push Viral Vector Production
The company has tailored its KUBio product line to include a standardized bioproduction environment designed specifically for viral vector production. In addition, Cytiva has developed a technical sol…
Article
Cell-Culture Advances Test Bioreactor Performance Models
Smith, staff engineer for single-use technologies in the BioProduction Division of Thermo Fisher Scientific.
In particular, the inexpensive computing power and excellent computational talent ent…
Article
Single-Use for Downstream Chromatography: Benefit or Hindrance?
“There are very few DSP unit operations that are not using single-use systems or components,” notes Donald Young, senior global product manager, Thermo Fisher Scientific, BioProduction Division. “Clar…
Article
Automating the Biomanufacturing Process
“Our ultimate goal is a ‘plugand-play’ system of automated bioproduction in which vendors, suppliers, and manufacturers all use equipment that ‘recognize’ each other, allowing for simple integration a…