Search results for " process intensification"

Article Single-use technologies in downstream process intensification
In bioprocessing, thorough cleaning is critical in order to take full benefit of the resin by removing impurities. When using conventional chromatography solutions, cleaning and cleaning validation …

Article Economic drivers and trade-offs in antibody purification processes
Through such process intensification methods, Kelley predicted that a platform consisting of two chromatography steps with high capacity resins would be able to handle an annual output of 10 tons.16 N…

Article Achieving Process Balance with Perfusion Bioreactors
As the industry pushes towards process intensification and even continuous processing solutions, this is the next logical step,” Levison asserts. The fact remains, however, that running a perfusio…

Article Moving PAT from Concept to Reality
The learning curve for process analytical technology has slowed widespread adoption. By Cynthia A. Challener alexlmx a- Stock.Adobe.com Process analytical technology (PAT) is…

Article Making the Move to Continuous Chromatography
“Even though regulatory agencies are very supportive and collaborative when it comes to companies introducing different process intensification initiatives, there is still, to my knowledge, no approve…

Article Reducing Cross-Contamination Risks in Process Chromatography
Advances in single-use technology are, in fact, facilitating process intensification and continuous processing. Continuous chromatography is a technique that many facilities are currently …

Article Optimizing Late-Stage and Commercial Cell-Culture Processes
• Increased focus on implementation of single-use technologies and process intensification. • Increased process complexity to achieve higher productivities. • Targeted integration cell-l…

Article Scaling Up Novel Therapies
Scaling Up Novel Therapies Platform processes have improved monoclonal antibody scale-up. Can they do the same for personalized therapies? By Agnes Shan…

Article Unifying Continuous Biomanufacturing Operations
The success of a truly integrated continuous processing platform relies on the collaborative efforts of upstream and downstream specialists. By Randi Hernandez When human cells travel throug…

Article Improving Upstream Predictability
In response to extreme cost pressures, companies are using or considering process intensification at every stage of upstream processing, says Andreas Castan, also strategic technology partnerships lea…

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