Search results for " process intensification"

Article Single-use technologies in downstream process intensification
In bioprocessing, thorough cleaning is critical in order to take full benefit of the resin by removing impurities. When using conventional chromatography solutions, cleaning and cleaning validation …

Article Economic drivers and trade-offs in antibody purification processes
Through such process intensification methods, Kelley predicted that a platform consisting of two chromatography steps with high capacity resins would be able to handle an annual output of 10 tons.16 N…

Article Achieving Process Balance with Perfusion Bioreactors
As the industry pushes towards process intensification and even continuous processing solutions, this is the next logical step,” Levison asserts. The fact remains, however, that running a perfusio…

Article Reducing Cross-Contamination Risks in Process Chromatography
Advances in single-use technology are, in fact, facilitating process intensification and continuous processing. Continuous chromatography is a technique that many facilities are currently …

Article Making the Move to Continuous Chromatography
“Even though regulatory agencies are very supportive and collaborative when it comes to companies introducing different process intensification initiatives, there is still, to my knowledge, no approve…

Article Scaling Up Novel Therapies
Scaling Up Novel Therapies Platform processes have improved monoclonal antibody scale-up. Can they do the same for personalized therapies? By Agnes Shan…

Article Unifying Continuous Biomanufacturing Operations
The success of a truly integrated continuous processing platform relies on the collaborative efforts of upstream and downstream specialists. By Randi Hernandez When human cells travel througho…

Article Optimizing Late-Stage and Commercial Cell-Culture Processes
• Increased focus on implementation of single-use technologies and process intensification. • Increased process complexity to achieve higher productivities. • Targeted integration cell-l…

Article Downstream Processing for Cell-Based Therapies
By Qasim A. Rafiq, Fernanda Masri With increasing numbers of advanced therapies—including cell and gene therapies—entering early- and late-stage clinical development, significant focus has been …

Article Biopharmaceutical Process Development: 2018 Lessons and 2019 Predictions
Process Intensification Process Development Forum readers spent a fair amount of time exploring ways to bring process intensification to their lines.  Continuous processing and scalability, fo…

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