Search results for " CHO"

Article A Risk-Based Genetic Characterization Strategy for Recombinant CHO Cell Lines Used for Clinical and Commercial Applications
Given this inherent genetic flux, recombinant genes (or transgenes, also referred to as the expression construct) expressed in CHO cells—used for therapeutic bioproduct development—can be subject to g…

Poster A rapid and efficient approach to media and feed optimization increasing CHO antibody production
As a result, every transfected CHO cell line can have a unique set of nutritional requirements for maximizing cell growth and recombinant protein production. Therefore, it is essential to develop an o…

Poster Benchmarking, scalability, and protein production in CHO cell culture
With the large number  of CHO clones in use, it is important to have a cell culture medium that supports high viable cell counts and  productivity with multiple cell clones. A precise balance of nutri…

Poster Utilization of high-throughput screening in the development of HyCell™ CHO medium
In order to overcome these limitations, this poster investigates the use of various high throughput screening (HTS) equipment in the development and testing of a medium designed for multiple CHO clone…

Article Optimization of Fed‑Batch Culture Conditions for a mAb‑Producing CHO Cell Line
This application note describes a broadly applicable and efficient workflow toward finding the optimal feed combination for the best-performing fed-batch processes.  An IgG1-producing CHO cell l…

Poster Development of DoE based fed-batch strategies for high-producing CHO cell cultures
Fed-batch culture is commonly employed to maximize cell and product concentrations in upstream mammalian cell culture processes. Typical standard platform processes rely on fixed-volume bolus feedin…

Poster Effects of feeding strategy on CHO cell performance in fed-batch cultures
ActiPro cell culture production medium is intended to be used in combination with Cell Boost 7a and 7b supplements to enhance recombinant protein production in fed-batch or perfusion processes. This…

Poster Scale-up of CHO fed-batch cultures in HyClone™ ActiPro™ medium supplemented with Cell Boost™ 7a and 7b
Comparing cell growth and recombinant protein production of multiple Chinese hamster ovary (CHO) cell clones when cultured in HyClone ActiPro basal medium and Cell Boost 7a and 7b feeding supplement…

Poster Optimization of product quality and yield in high-performing fed-batch CHO cell cultures
This poster summarizes data from studies of product quality of a human monoclonal antibody (IgG1) produced from Chinese hamster ovary (CHO) cells cultured in fed-batch mode.

Tip One-step filter clarification of CHO cells
Looking for a simple and rapid filtration method for clarifying CHO cultures that eliminates centrifugation and its associated manual manipulations? Just turn on the pump to clarify and sterile filt…

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